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Central serous chorioretinopathy and risk of ischaemic stroke: a population-based cohort study
  1. Der-Chong Tsai1,2,
  2. Chin-Chou Huang3,4,5,6,
  3. Shih-Jen Chen7,
  4. Pesus Chou2,
  5. Chia-Min Chung8,
  6. Wan-Leong Chan5,9,
  7. Po-Hsun Huang4,5,10,
  8. Tseng-Ji Chen11,12,
  9. Shing-Jong Lin4,5,6,10,
  10. Jaw-Wen Chen3,4,5,6,
  11. Hsin-Bang Leu4,5,9,10
  1. 1Department of Ophthalmology, National Yang-Ming University Hospital, Yilan, Taiwan
  2. 2Institute of Public Health and Community Medicine Research Center, National Yang-Ming University, Taipei, Taiwan
  3. 3Institute of Pharmacology, National Yang-Ming University, Taipei, Taiwan
  4. 4Cardiovascular Research Center, School of Medicine, National Yang-Ming University, Taipei, Taiwan
  5. 5Division of Cardiology, Department of Medicine, Taipei Veterans General Hospital, Taipei, Taiwan
  6. 6Department of Medical Research and Education, Taipei Veterans General Hospital, Taipei, Taiwan
  7. 7Department of Ophthalmology, Taipei Veterans General Hospital, Taipei, Taiwan
  8. 8Institute of Biomedical Sciences, Academia Sinica, Taipei, Taiwan
  9. 9Healthcare and Management Center, Taipei Veterans General Hospital, Taipei, Taiwan
  10. 10Institute of Clinical Medicine, National Yang-Ming University, Taipei, Taiwan
  11. 11Department of Family Medicine, Taipei Veterans General Hospital, Taipei, Taiwan
  12. 12Institute of Hospital and Health Care Administration, National Yang-Ming University, Taipei, Taiwan
  1. Correspondence to Dr Hsin-Bang Leu, No. 201, Sec. 2, Shih-Pai Road, Taipei 112, Taiwan; hbleu{at}vghtpe.gov.tw

Abstract

Background Central serous chorioretinopathy (CSCR) is a common maculopathy that features choroidal circulatory disturbance. This population-based cohort study aimed to explore the relationship between CSCR and the future development of ischaemic stroke.

Methods Data were obtained from Taiwan's national health insurance research database. From 2000 to 2007, 1814 patients with newly diagnosed CSCR were eligible for inclusion in the study cohort. Using stratified random sampling, 9648 enrollees matched with the study subjects in terms of sex, age, monthly income, geographical location and time of enrolment were selected as the control group. Stroke-free survival analysis was assessed using a Kaplan–Meier method. Cox proportional hazard regressions were performed to calculate the HR of ischaemic stroke for the two groups after adjusting for possible confounding variables.

Results Of the sampled patients, 45 (2.5%) from the CSCR cohort and 157 (1.6%) from the control group developed ischaemic stroke during a mean follow-up period of 3.9±2.2 years. CSCR patients had a significantly higher incidence of ischaemic stroke than those without a diagnosis of CSCR (p=0.003). After adjusting for age, sex and chronic comorbidities at baseline, CSCR patients were found to have a 1.56-fold (95% CI 1.11 to 2.18, p=0.010) greater risk of a subsequent ischaemic stroke than the matched controls.

Conclusions CSCR is an independent indicator for the increased risk of subsequent ischaemic stroke development.

  • Epidemiology
  • Retina

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