Footnotes

• Contributors TLJ devised the original concept that was modified in discussion with LK and SP. GT devised the economic model and provided the output data and then LK used this to prepare the table and figure. TLJ wrote the first draft that was critically reviewed by all authors.

• Funding This original work to develop the methodology used in this project was supported by funding from NeoVista. No grant was made to support the work herein.

• Competing interest TLJ and SP receive research grant funding from NeoVista for other projects. TLJ also received research grant funding from Novartis and Oraya (competing companies). LK and GT received funding from NeoVista.

• Provenance and peer review Not commissioned; externally peer reviewed.

• Data sharing statement Data are presented in full in this paper.