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Indocyanine green enhanced transpupillary thermotherapy in combination with ophthalmic artery chemosurgery for retinoblastoma
  1. Jasmine H Francis1,
  2. David H Abramson1,2,3,
  3. Scott E Brodie1,4,
  4. Brian P Marr1,3
  1. 1Department of Ophthalmic Oncology, Memorial Sloan-Kettering Cancer Center, New York, New York, USA
  2. 2Department of Ophthalmology, New York-Presbyterian Hospital, New York, New York, USA
  3. 3Department of Ophthalmology, Weill-Cornell Medical Center, New York, New York, USA
  4. 4Department of Ophthalmology, Mount Sinai School of Medicine, New York, New York, USA
  1. Correspondence to Dr David H Abramson, Ophthalmic Oncology Service, Memorial Sloan-Kettering Cancer Center, 70 East 66th Street, New York, NY 10065, USA; abramsod{at}mskcc.org

Abstract

Purpose Review our experience in the use of indocyanine green (ICG) enhanced transpupillary thermotherapy (TTT) in combination with ophthalmic artery chemosurgery for retinoblastomas unresponsive to standard TTT.

Methods Single centre, retrospective study of 16 eyes in 13 retinoblastoma patients treated with TTT and ICG via indirect ophthalmoscope: 23 treatments of 16 eyes, with a mean follow-up of 12.1 months (range 3–35 months). Outcome measures included tumour response and electroretinogram.

Results Treatment resulted in significant tumour regression in all eyes: 13 eyes with well-differentiated characteristics, 2 with implanting vitreous seeds and 1 eye refractory to traditional TTT. ERG function was retained in all eyes.

Conclusions ICG-enhanced TTT with ophthalmic artery chemosurgery can effectively treat retinoblastoma refractory to conventional focal treatments without deleterious ocular side effects.

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