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Morphological assessments of the photoreceptors can be useful in estimating the disease progression in retinitis pigmentosa (RP).1–3 Using spectral-domain optical coherence tomography, the external limiting membrane (ELM) and cone outer segment tips (COST) can be clearly detected in addition to photoreceptor inner/outer segment junction (IS/OS). To date, the IS/OS as well as the ELM and COST have been analysed after macular surgery.4 ,5 In RP patients, however, changes of the COST line and correlations among the IS/OS, ELM and COST lines remain unclear.
We have already reported that the IS/OS length was significantly correlated with visual acuity or retinal sensitivity and that the progressive IS/OS shortening is associated with worsening of visual function during RP progression.1 ,2 The purposes of this study were to examine the changes of the COST line in RP patients and to investigate the correlations among the IS/OS, ELM and COST lines.
After obtaining approval from the Institutional Review Board and informed consent, this study was done on 263 eyes of 133 consecutive patients with RP. RP patients were …