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Looking deeper into the tumour cell genome for a better diagnosis, a better understanding of cell biology, a better prognostication and finally a better treatment
  1. Laurence Desjardins
  1. Correspondence to Dr Laurence Desjardins, Department of Ophthalmic Oncology, Institut Curie, 26 rue d'ulm, Paris 75005, France; laurence.desjardins{at}curie.net

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During the last 10 years, considerable progress has been made in cancer genetics and many cancer diagnoses now rely on molecular biology. Chromosomal abnormalities have been first studied by karyotype analysis then fluorescence in situ hybridisation (FISH), and now new techniques are available, like comparative genomic hybridisation and single nucleotide polymorphism (SNP) arrays, that are becoming more and more affordable in molecular pathology labs. New technologies for genome-wide DNA sequencing are now revealing specific and unbiased information on cancer initiation …

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