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Macular telangiectasia (MacTel) type 2 is a bilateral disease of unknown origin exhibiting characteristic changes of the macular deep capillary network and neurosensory retina.1–3 Originally considered a predominantly vascular disorder, the introduction of novel imaging techniques has altered prevailing impressions of its underlying pathophysiology, suggesting a significant role of structural changes to the neurosensory retina. The MacTel study, a major multicenter observational study, attempts to shed light on the natural history of the disease and to identify optimal surrogates of disease progression that could be used as end points in interventional clinical trials. In view of the exploratory nature of the study, various imaging modalities were used at baseline and on annual follow-up visits to investigate their contribution to disease diagnosis and their role in offering clues on disease progression. These modalities included colour fundus imaging (CFI), fundus fluorescein angiography (FFA), autofluorescence imaging (AF), optical coherence tomography (OCT) and indocyanine green angiography (ICGA). All obtained images were sent to the Reading Centre at Moorfields Eye Hospital, UK, where the diagnosis was confirmed. During the MacTel study, it has been established that there are characteristic changes on CFI, AF, FFA and OCT that uniquely identify the disease.4 ,5
The primary aim of this project is to determine whether ICGA is helpful in establishing the diagnosis of MacTel and, therefore, whether its inclusion in the MacTel imaging protocol was justified. The secondary aim was to identify any changes specific to MacTel on ICGA over the course of …
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