Article Text

other Versions

PDF
Longitudinal changes in anterior chamber depth and axial length in Asian subjects after trabeculectomy surgery
  1. Rahat Husain1,
  2. Wen Li2,3,
  3. Gus Gazzard4,
  4. Paul J Foster4,
  5. Paul T Chew5,
  6. Francis T Oen1,
  7. Rachel Phillips2,
  8. Peng T Khaw4,
  9. Steve K Seah1,
  10. Tin Aung1,5
  1. 1Singapore Eye Research Institute and Singapore National Eye Centre, Singapore
  2. 2Singapore Clinical Research Institute, Singapore
  3. 3Centre for Quantitative Medicine, Duke-NUS Graduate Medical School, Singapore
  4. 4NIHR Biomedical Research Centre in Ophthalmology, Moorfields Eye Hospital and UCL Institute of Ophthalmology, London, UK
  5. 5Yong Loo Lin School of Medicine, National University of Singapore, Singapore
  1. Correspondence to Professor T Aung, Singapore National Eye Centre, 11 Third Hospital Avenue, Singapore 168751, Singapore; aung.tin{at}snec.com.sg

Abstract

Background/aims To investigate longitudinal changes in anterior chamber depth (ACD) and axial length (AXL) over 5 years after trabeculectomy surgery in Asian patients with primary glaucoma, and to identify factors associated with these changes.

Methods In this prospective cohort study, phakic subjects with primary glaucoma who underwent trabeculectomy had ACD and AXL measured over 5 years. The effect of intraocular pressure (IOP) on ACD and AXL was determined. Subjects were divided into two groups (high or low fluctuation of ACD/AXL) and factors were compared to determine if there were factors associated with greater fluctuation.

Results 122 subjects were analysed. The majority of subjects were male (75.4%) and Chinese (77%). ACD and AXL were shallower/shorter compared with baseline at all postoperative visits, with a mean decrease of 0.11 mm (95% CI 0.07 to 0.15 mm, p<0.01) and 0.16 mm (95%CI 0.11 to 0.20 mm, p<0.01), respectively. Patients with primary open angle glaucoma (POAG) had higher odds of fluctuations in longitudinal measurements of ACD (OR=8.74, p<0.01) and AXL (OR=5.60, p<0.01) compared with patients with primary angle closure glaucoma. For every 1 mm Hg decrease in IOP, ACD and AXL decreased by 0.02 mm (p<0.01) and 0.01 mm (p=0.03), respectively, for POAG patients with emmetropia or mild myopia.

Conclusions Trabeculectomy resulted in a decrease in both ACD and AXL, and these changes were persistent over a period of 5 years.

  • Glaucoma
  • Treatment Surgery
  • Anterior chamber

Statistics from Altmetric.com

Request permissions

If you wish to reuse any or all of this article please use the link below which will take you to the Copyright Clearance Center’s RightsLink service. You will be able to get a quick price and instant permission to reuse the content in many different ways.