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In glaucoma, both visual acuity (VA) and visual field (VF) sensitivity deteriorate, with consequential impact on the vision-related quality of life of patients with the disease.1 In general, VA is largely unaffected until an advanced stage of glaucoma due to the large number of surviving retinal ganglion cells in the macular area in contrast to the peripheral region.2 Nevertheless, to date, the relationship between the decline in VA and the reduction of VF sensitivity has not been investigated in detail. The purpose of the current study is to analyse the relationship between VA and central VF sensitivity in advanced glaucoma. The study design is a case series on multiple patients with similar characteristics, but without a comparison group.
In all, 104 eyes from 52 patients with advanced glaucoma (27 cases with primary open angle glaucoma, 17 cases with normal tension glaucoma, three cases with primary angle closure glaucoma and five cases with secondary open angle glaucoma) were investigated. Advanced glaucoma was defined as a mean deviation (MD) <−20 dB on the 24-2 VF (Humphrey …