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Diagnostic ability of a new method for measuring haemoglobin levels in the optic nerve head in multiple sclerosis patients
  1. Maria Pilar Bambo1,2,
  2. Elena Garcia-Martin1,2,
  3. Susana Perez-Olivan1,2,
  4. Jose Sigut3,
  5. Francisco Fumero3,
  6. Juan Luis Fuentes1,2,
  7. Jose R Ara4,
  8. Jesus Martin4,
  9. Jose M Larrosa1,2,
  10. Manuel Gonzalez-De la Rosa5
  1. 1Ophthalmology Department, Miguel Servet University Hospital, Zaragoza, Spain
  2. 2Aragones Institute of Health Sciences, Zaragoza, Spain
  3. 3Systems Engineering Department, University of La Laguna, La Laguna, Spain
  4. 4Neurology Department, Miguel Servet University Hospital, Zaragoza, Spain
  5. 5Ophthalmology Department, University of La Laguna, La Laguna, Spain
  1. Correspondence to Dr Maria P Bambo, Ophthalmology Department, Miguel Servet University Hospital, C/Padre Arrupe, Consultas Externas de Oftalmologia, Zaragoza 50009, Spain; mpbamborubio{at}gmail.com

Abstract

Aims To evaluate a new method for measuring haemoglobin (Hb) levels and quantifying the colour changes in the optic nerve head of multiple sclerosis (MS) patients to detect axonal loss and consequently optic disc atrophy.

Material and methods 40 MS patients and 40 age and sex-matched healthy subjects were included in this prospective cross-sectional study and underwent a full ophthalmological examination, including three photographs of the optic disc. The Laguna ONhE (‘optic nerve hemoglobin’; Insoft SL, Tenerife, Spain) software was used to obtain the Hb analysis in each of the 24 sectors and average Hb of optic disc photographs acquired. Reproducibility of measurements provided by Laguna ONhE program was analysed.

Results MS patients showed significant reduction of optic disc Hb percentages in average Hb (58.99% in MS, 65.39% in healthy subjects; p<0.001) and in almost all analysed sectors with the largest differences in temporal sectors. Laguna ONhE program showed good reproducibility measuring Hb percentages in MS patients and healthy subjects.

Conclusions Measurements of optic disc Hb levels obtained with Laguna ONhE software had good ability detecting optic atrophy and axonal loss in MS patients. This method had good reliability and is easy to implement in routine clinical practice.

  • Optic Nerve
  • Diagnostic Tests/Investigation

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