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Clinical science
Change in choroidal thickness and axial length with change in intraocular pressure after trabeculectomy
  1. Osamah Saeedi1,
  2. Angelique Pillar1,
  3. Joan Jefferys2,
  4. Karun Arora2,
  5. David Friedman2,
  6. Harry Quigley2
  1. 1Department of Ophthalmology and Visual Sciences, University of Maryland School of Medicine, Baltimore, Maryland, USA
  2. 2Glaucoma Center of Excellence, Wilmer Eye Institute, Johns Hopkins University School of Medicine, Baltimore, Maryland, USA
  1. Correspondence to Dr Osamah Saeedi, Department of Ophthalmology and Visual Sciences, University of Maryland, 419 W. Redwood Street, Suite 420, Baltimore, MD 21201, USA; osaeedi{at}som.umaryland.edu

Abstract

Background/aims We studied the change in choroidal thickness (CT) and axial length (AL) after intraocular (IOP) changes produced by trabeculectomy.

Methods Twenty-one eyes of 20 patients were studied preoperatively, and then postoperatively at 1 week, 1, 3, and 6 months. Variables measured included IOP, AL, keratometry, refractive error, central corneal thickness, and average CT in the posterior 6 mm centred on the fovea using enhanced depth imaging spectral domain optical coherence tomography (OCT).

Results OCT images in 17 eyes (58 images, preoperatively and postoperatively) were of sufficient quality to determine CT. In every patient, CT increased with IOP lowering postoperatively. For each 1 mm Hg decrease in IOP, there was a mean increase of 3.4 µm in CT (p<0.0001; univariate regression, 95% CI 2.5 to 4.3). This represented a CT increase of 1.7% per mm Hg decrease (p<0.0001; 95% CI 1.3 to 2.0%). AL decreased by 6.8 µm per mm Hg decrease in IOP (p<0.0001, univariate regression, 95% CI 4.9 to 8.6).

Conclusions The dynamic relationship between change in IOP and the state of sclera and choroid was confirmed by sequential measurements in postoperative trabeculectomy patients, providing estimates of the magnitude of choroidal swelling and scleral volume decrease with IOP lowering.

  • Glaucoma
  • Choroid
  • Intraocular pressure
  • Imaging

https://doi.org/10.1136/bjophthalmol-2013-304433

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