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Association between variants A69S in ARMS2 gene and response to treatment of exudative AMD: a meta-analysis
  1. Zizhong Hu,
  2. Ping Xie,
  3. Yuzhi Ding,
  4. Dongqing Yuan,
  5. Qinghuai Liu
  1. Department of Ophthalmology, The First Affiliated Hospital of Nanjing Medical University, Nanjing, People's Republic of China
  1. Correspondence to Dr Qinghuai Liu, Department of Ophthalmology, The First Affiliated Hospital of Nanjing Medical University, 300#, Guangzhou Road, Nanjing, Jiangsu 210029, People's Republic of China; liuqh{at}njmu.edu.cn

Abstract

A study was undertaken to investigate the association between A69S in age-related maculopathy susceptibility 2 (ARMS2) and the response to anti-angiogenesis treatment in exudative age-related macular degeneration (AMD). A literature-based meta-analysis was performed of studies relevant to A69S and the response to anti-angiogenesis treatment. PubMed, Web of Science, China National Knowledge Infrastructure (CNKI) and Sinomed databases were used to retrieve articles up to July 2014. Pooled ORs and 95% CIs were estimated using fixed and random effects models in Stata V.9.0. Q-statistic testing was used to assess heterogeneity. Twelve articles comprising 2389 cases were included in the final meta-analysis. The analysis of the overall population indicated a statistically significant association between A69S and the response to anti-angiogenesis treatment in exudative AMD (GG vs TT: OR 1.34 (95% CI 1.01 to 1.77), p=0.039; GT vs TT: OR 1.58 (95% CI 1.08 to 2.31), p=0.018; GG+GT vs TT: OR 1.74 (95% CI 1.19 to 2.52), p=0.004). In subgroup analysis, A69S appeared more likely to be a predictor for anti-angiogenic response in the East Asian population (GG vs TT: OR 1.65 (95% CI 1.02 to 2.68), p=0.042; GT vs TT: OR 1.66 (95% CI 1.17 to 2.37), p=0.005; GG+GT vs TT: OR 1.82 (95% CI 1.07 to 3.10), p=0.027; G vs T: OR 1.56 (95% CI 1.01 to 2.41)). However, no statistical significance was found in the Caucasian subgroup analysis. This study shows an association between A69S polymorphism in the ARMS2 gene and the anti-angiogenesis treatment response. A69S could be considered predictive of the anti-angiogenic effects, especially in Asian populations.

  • Angiogenesis
  • Genetics
  • Treatment Medical
  • Retina
  • Neovascularisation

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