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Intraocular pressure and coronary artery calcification in asymptomatic men and women
  1. Sungmin Ye1,
  2. Yoosoo Chang1,2,
  3. Chan-Won Kim1,
  4. Min-Jung Kwon1,3,
  5. Yuni Choi1,
  6. Jiin Ahn1,
  7. Joon Mo Kim4,
  8. Hyun Soo Kim1,5,
  9. Hocheol Shin1,6,
  10. Seungho Ryu1,2
  1. 1Center for Cohort Studies, Total Healthcare Center, Kangbuk Samsung Hospital, Sungkyunkwan University, School of Medicine, Seoul, Korea
  2. 2Department of Occupational and Environmental Medicine, Kangbuk Samsung Hospital, Sungkyunkwan University, School of Medicine, Seoul, Korea
  3. 3Department of Laboratory Medicine, Kangbuk Samsung Hospital, Sungkyunkwan University, School of Medicine, Seoul, Korea
  4. 4Department of Ophthalmology, Kangbuk Samsung Hospital , Sungkyunkwan University School of Medicine, Seoul, Korea
  5. 5Department of Anesthesiology and Pain Medicine, Kangbuk Samsung Hospital, Sungkyunkwan University, School of Medicine, Seoul, Korea
  6. 6Department of Family Medicine, Kangbuk Samsung Hospital, Sungkyunkwan University, School of Medicine, Seoul, Korea
  1. Correspondence to Dr Seungho Ryu, Department of Occupational and Environmental Medicine, Kangbuk Samsung Hospital, Sungkyunkwan University, School of Medicine, Samsung Main Building B2, 250, Taepyung-ro 2ga, Jung-gu, Seoul 100-742, Korea; sh703.yoo@gmail.com Dr Yoosoo Chang, Department of Occupational and Environmental Medicine, Kangbuk Samsung Hospital, Sungkyunkwan University, School of Medicine, Samsung Main Building B2, 250, Taepyung-ro 2ga, Jung-gu, Seoul 100-742, Korea; yoosoo.chang@gmail.com

Abstract

Objective We evaluated the relationship between intraocular pressure (IOP) and the risk of coronary artery calcification as a predictable marker of cardiovascular disease (CVD) in a large study of asymptomatic men and women.

Methods A cross-sectional study was performed in 10 732 asymptomatic men and women without diagnosed CVD or glaucoma. Coronary artery calcium (CAC) was measured by cardiac CT. The IOPs of all participants were measured by experienced nurses with a non-contact tonometer and automatic air puff control. Logistic regression was used to estimate the OR (95% CI) for the presence of CAC (score >0) with IOP quartiles.

Results The prevalence of detectable CAC was 13.7% in men and 4.3% in women. Increasing levels of right IOP were significantly associated with an increased prevalence of CAC. After adjusting for age, sex, smoking, alcohol intake, physical activity, body mass index, educational level, centre, family history of CVD, use of dyslipidaemia medication, diabetes, hypertension, total cholesterol, high density lipoprotein cholesterol and triglycerides, the ORs for CAC score >0, comparing 2–4 quartiles of the right IOP to the lowest quartiles, were 1.32 (95% CI 1.09 to 1.59), 1.20 (95% CI 0.98 to 1.46), and 1.28 (95% CI 1.05 to 1.56), respectively. These associations did not differ by clinically relevant subgroups.

Conclusions A higher IOP is significantly associated with the presence of CAC regardless of conventional cardiovascular risk factors. The present study provides more insight into understanding the process of subclinical atherosclerosis in CVD and the relationship with a higher IOP as a common pathophysiology.

  • Epidemiology
  • Intraocular pressure

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