Article Text

other Versions

PDF
Risk factors for the development of ocular graft-versus-host disease (GVHD) dry eye syndrome in patients with chronic GVHD
  1. Jay Ching Chieh Wang1,
  2. Joshua C Teichman2,
  3. Majd Mustafa1,
  4. Heather O'Donnell1,
  5. Raewyn Broady3,
  6. Sonia N Yeung1
  1. 1Department of Ophthalmology and Visual Sciences, University of British Columbia, Vancouver, British Columbia, Canada
  2. 2Department of Ophthalmology, University of Ottawa, Ottawa, Ontario, Canada
  3. 3Bone Marrow Transplant Unit, Department of Medicine, University of British Columbia, Vancouver, British Columbia, Canada
  1. Correspondence to Dr Sonia N Yeung,  Department of Ophthalmology and Visual Sciences, University of British Columbia, 616-2525 Willow Street, Vancouver, British Columbia, Canada V5Z 1K1; sonia.y{at}gmail.com

Abstract

Background To investigate the factors associated with the development of ocular graft-versus-host disease (oGVHD) dry eye syndrome (DES) in patients with chronic GVHD (cGVHD) after receiving allogenic haematopoietic stem cell transplantation (AHSCT)

Methods A retrospective chart review of patients receiving AHSCT between 1998 and 2013 at the Bone Marrow Transplant Unit of the British Columbia Cancer Agency was carried out. Demographic and clinical data from both donors and recipients were obtained. The diagnostic criteria for the development of oGVHD DES from the National Institutes of Health were used to identify patients with the disease. Descriptive and inferential statistics were carried out.

Results A total of 146 patients with a median follow-up time of 24.0 months (range 11.3–249.7 months) were included in this study. Sixty-six (45.2%) patients were women. Seventy-seven (52.7%) patients had oGVHD DES. The median age of patients was 57 years (range 25–71 years). Compared with other ethnicities, Caucasian patients were less likely to develop oGVHD DES, with an OR of 0.29 (p=0.01). Patients who received a transplant from Epstein–Barr-positive donors had a higher prevalence of oGVHD DES (OR=4.39, p=0.01). This was also found in patients with the following systemic involvement of cGVHD: grade 1–3 cGVHD skin involvement (OR=1.57, p=0.01), oral involvement (OR=2.51, p=0.01) and liver involvement (p=0.04). Patients with grade 2–3 overall cGVHD were also more susceptible to oGVHD DES (OR=2.72, p<0.001).

Conclusions This study identified risk factors associated with a higher prevalence of oGVHD DES in post-AHSCT patients with cGVHD.

  • Cornea
  • Ocular surface

Statistics from Altmetric.com

Request permissions

If you wish to reuse any or all of this article please use the link below which will take you to the Copyright Clearance Center’s RightsLink service. You will be able to get a quick price and instant permission to reuse the content in many different ways.