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Choroidal maps in non-exudative age-related macular degeneration
  1. Vittorio Capuano1,
  2. Eric H Souied1,2,
  3. Alexandra Miere1,
  4. Camille Jung2,3,
  5. Eliana Costanzo1,
  6. Giuseppe Querques1,2
  1. 1Department of Ophthalmology, Centre Hospitalier Intercommunal de Creteil University Paris Est Creteil, Creteil, France
  2. 2Groupe de Recherche Clinique Macula, Universite Paris Est, Creteil, France
  3. 3Centre de Ressources Biologiques et Centre de Recherche Clinique du Centre Hopitalier Intercommunal de Créteil, Creteil, France
  1. Correspondence to Dr Giuseppe Querques, Department of Ophthalmology, Centre Hospitalier Intercommunal de Creteil, 40 Avenue de Verdun, Creteil 94000, France; giuseppe.querques{at}hotmail.it

Abstract

Purpose To compare choroidal thickness maps (CMs) in patients with non-exudative age-related macular degeneration (AMD) and control subjects using swept source optical coherence tomography (Swept-OCT).

Methods CMs were automatically measured in the different Early Treatment of Diabetic Retinopathy Study (ETDRS) sectors in eyes with early non-exudative AMD (early AMD) (large soft drusen: group 1; reticular pseudodrusen: group 2 and variable combination of large soft drusen and reticular pseudodrusen: group 3), late non-exudative AMD/geographic atrophy (GA) (late AMD) (group 4) and control subjects (group 5). Fundus autofluorescence (FAF) images were overlaid to sectorial CMs in late-AMD group (group 4).

Results A total of 90 eyes (90 patients, 79.7±8.34 years old) were included. CMs were significantly reduced in early-AMD group 2 and 3 and late-AMD group 4 compared with control subjects in group 5 and early-AMD group 1 (large soft drusen alone) for each ETDRS sectors (p<0.05). No difference in CMs was found by comparing group 2 with 3 and group 2 and 3 with group 4. No statistical differences in CMs were found among ETDRS sectors with >50% absence of FAF (‘Hypo FAF’ sectors) resulting from retinal atrophy versus ≤50% absence of FAF (‘hyper/iso FAF’ sectors owing to >50% preserved retina) in late-AMD group (group 4) (p=0.328).

Conclusions CMs appeared thinner in early non-exudative AMD with intermediate distribution of reticular pseudodrusen versus control subjects and early non-exudative AMD with drusen alone. Same results were found in the group with variable combination of large soft drusen and reticular pseudodrusen. In GA eyes, a choroidal thinning could be detected independently of the retinal pigmented epithelium status.

  • Imaging
  • Retina
  • Degeneration

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