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Reproducibility and repeatability of foveal avascular zone measurements in healthy subjects by optical coherence tomography angiography
  1. Paolo Carpineto1,
  2. Rodolfo Mastropasqua2,
  3. Giorgio Marchini2,
  4. Lisa Toto1,
  5. Marta Di Nicola3,
  6. Luca Di Antonio1
  1. 1Ophthalmology Clinic, Department of Medicine and Aging Sciences, High-Tech National Center in Ophthalmology, University “G. d'Annunzio” Chieti-Pescara, Chieti, Italy
  2. 2Ophthalmology Clinic, Department of Neurological and Visual Science, University of Verona, Verona, Italy
  3. 3Department of Experimental and Clinical Sciences, Laboratory of Biostatistics, University “G. d'Annunzio” Chieti-Pescara, Chieti, Italy
  1. Correspondence to Dr R Mastropasqua, Ophthalmology Clinic, Department of Neurological and Visual Science, University of Verona, Verona 37124, Italy; rodorodolfomastrorodo{at}hotmail.com

Abstract

Background/aims To assess the reproducibility and repeatability of foveal avascular zone (FAZ) area measurements using optical coherence tomography angiography (OCT-A) in healthy subjects.

Methods Sixty healthy volunteers (60 eyes) were subjected to FAZ area measurements by means of high speed and high resolution spectral-domain OCT (SD-OCT) XR Avanti with the split-spectrum amplitude decorrelation angiography algorithm by two experienced examiners in two different sessions.

Results The mean±SD age of the subjects was 28.9±7.6 years. Overall FAZ areas measured by the first and second observer were 0.251±0.096 mm2 and 0.252±0.096 mm2, respectively. Within subjects, the coefficients of variations were 1.83% (95% CI 1.51% to 2.20%) and 1.86% (95% CI 1.33% to 2.43%) for the first and second observers, respectively. The coefficient of repeatability average measurements of FAZ area were 0.015 mm2 and 0.013 mm2 for the first and second observers, respectively. The intraclass correlation coefficient values were 0.997 (95% CI 0.995 to 0.998) and 0.998 (95% CI 0.996 to 0.999) for the first and second observers, respectively. Inter- and intraobserver concordance correlation coefficients ranged from 0.994 (95% CI 0.990 to 0.977) to 0.999 (95% CI 0.997 to 0.999) and from 0.997 (95% CI 0.995 to 0.998) to 0.996 (95% CI 0.994 to 0.998), respectively.

Conclusions FAZ area measurements by means of OCT-A showed excellent reproducibility and repeatability in healthy eyes. OCT-A is a non-invasive diagnostic method, and its reliability makes it an interesting potential diagnostic tool for disease detection and follow-up in retinal pathologies involving foveal microcirculation.

  • Anatomy
  • Angiogenesis
  • Macula
  • Retina

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