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Relationship between high serum ferritin level and glaucoma in a South Korean population: the Kangbuk Samsung health study
  1. Hyo Jung Gye1,
  2. Joon Mo Kim1,
  3. Chungkwon Yoo2,
  4. Seong Hee Shim1,
  5. Yu Sam Won3,
  6. Ki Chul Sung4,
  7. Mi Yeon Lee5,
  8. Ki Ho Park6
  1. 1Department of Ophthalmology, Sungkyunkwan University School of Medicine, Kangbuk Samsung Hospital, Seoul, Korea
  2. 2Department of Ophthalmology, Korea University College of Medicine, Seoul, Korea
  3. 3Department of Neurosurgery, Sungkyunkwan University School of Medicine, Kangbuk Samsung Hospital, Seoul, Korea
  4. 4Department of Internal Medicine, Sungkyunkwan University School of Medicine, Kangbuk Samsung Hospital, Seoul, Korea
  5. 5Division of Biostatistics, Department of Medical Information, Kangbuk Samsung Hospital, Seoul, Korea
  6. 6Department of Ophthalmology, Seoul National University College of Medicine, Seoul National University Hospital, Seoul, Korea
  1. Correspondence to Dr Joon Mo Kim, Department of Ophthalmology, Sungkyunkwan University School of Medicine, Kangbuk Samsung Hospital, 108 Pyungdong Jongrogu, Seoul 110-746, Korea; kjoonmo1{at}gmail.com

Abstract

Background/aims To investigate the association between serum ferritin levels and glaucoma in a South Korean population.

Methods This retrospective cross-sectional study included 164 029 subjects who underwent screening at Kangbuk Samsung Hospital Health Screening Center between August 2012 and July 2013. All subjects underwent a physical examination, answered sociodemographic and behavioural questions, and provided samples for laboratory analyses. A digital fundus photograph of both eyes was taken, and all photographs were reviewed by ophthalmologists. The ophthalmologists determined if an eye had glaucoma based on criteria set forth by the International Society of Geographical and Epidemiological Ophthalmology and the appearance of the retinal nerve fibre layer and optic disc.

Results The mean serum ferritin level was 56.98 ng/mL in women and 223.82 ng/mL in men. After adjusting for age, serum iron, total iron-binding capacity (TIBC), transferrin saturation, white blood cell (WBC) count, high-sensitivity C-reactive protein (HsCRP) and total vitamin D level, males in the highest quartile for serum ferritin level had a higher OR for glaucoma than males in the lowest quartile (OR=1.176, 95% CI 1.030 to 1.342, p=0.016); we did not observe this relationship among women. Other markers of iron metabolism, such as iron level, transferrin saturation and TIBC, and inflammation measures, including WBC, HsCRP and total vitamin D, were not associated with glaucoma.

Conclusions High serum ferritin level was associated with a high risk of glaucoma in men, but not in women. Because serum ferritin is related to oxidative stress and inflammation, it might play a role in glaucoma development.

  • Inflammation
  • Glaucoma
  • Pathology
  • Biochemistry

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