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Changes in subfoveal choroidal thickness and reduction of serum levels of vascular endothelial growth factor in patients with POEMS syndrome
  1. Hirotaka Yokouchi1,
  2. Takayuki Baba1,
  3. Sonoko Misawa2,
  4. Masayasu Kitahashi1,
  5. Toshiyuki Oshitari1,
  6. Satoshi Kuwabara2,
  7. Shuichi Yamamoto1
  1. 1Department of Ophthalmology and Visual Science, Graduate School of Medicine, Chiba University, Chiba, Japan
  2. 2Department of Neurology, Graduate School of Medicine, Chiba University, Chiba, Japan
  1. Correspondence to Dr Hirotaka Yokouchi, Department of Ophthalmology and Visual Science, Chiba University Graduate School of Medicine, 1-8-1 Inohana, chuo-ku, Chiba city, Chiba 260-0856, Japan; yokouchi123{at}peace.ocn.ne.jp

Abstract

Aims To determine the changes in the subfoveal choroidal thickness (CT), the foveal thickness (FT) and the serum level of vascular endothelial growth factor (VEGF) after thalidomide treatment in patients with polyneuropathy, organomegaly, endocrinopathy, monoclonal gammopathy and skin changes (POEMS) syndrome.

Methods We studied 13 left eyes of 13 treatment-naïve patients with POEMS syndrome. The subfoveal CT and FT were determined by enhanced depth imaging optical coherence tomography, and the serum level of VEGF was determined by ELISA at the baseline and at 6 months after thalidomide treatment. The correlations in the serum level of VEGF and the subfoveal CT or the FT at the baseline and at 6 months after treatment were determined.

Results Together with the reduction in the serum level of VEGF, the subfoveal CT was also reduced significantly from 439.1±66.5 µm at the baseline to 307.2±75.4 µm at 6 months (p=0.001). The mean FT at the baseline was 236.4±30.7 µm which did not change significantly at 6 months at 228.1±33.1 µm (p>0.05). The change in the subfoveal CT was significantly and linearly correlated with the change in the serum level of VEGF at 6 months after treatment (r=0.67, p=0.011).

Conclusions The significant correlation between the CT and the serum level of VEGF may offer clues on the pathogenesis of ocular diseases of POEMS syndrome and on the role of serum VEGF on the choroid.

  • Choroid
  • Retina
  • Treatment Medical

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Footnotes

  • Contributors HY, TB and SS: design and conduct of study; HY, TB, MK, TO and SM: collection, management, analysis and interpretation of the data; HY, TB, SY and SK: preparation, review or approval of the manuscript.

  • Competing interests None declared.

  • Patient consent Obtained.

  • Ethics approval The Institutional Review Board of Chiba University Graduate School of Medicine.

  • Provenance and peer review Not commissioned; externally peer reviewed.

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