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Early postnatal hyperglycaemia is a risk factor for treatment-demanding retinopathy of prematurity
  1. Carina Slidsborg1,
  2. Louise Bering Jensen1,
  3. Steen Christian Rasmussen2,
  4. Hans Callø Fledelius1,
  5. Gorm Greisen3,
  6. Morten de la Cour1
  1. 1Department of Ophthalmology, Copenhagen University Hospital, Rigshospitalet, Copenhagen, Denmark
  2. 2Department of Clinical Microbiology, Copenhagen University Hospital, Hvidovre Hospital, Hvidovre, Denmark
  3. 3Department of Neonatology, Copenhagen University Hospital, Rigshospitalet, Copenhagen, Denmark
  1. Correspondence to Carina Slidsborg, Department of Ophthalmology, Rigshospitalet, Nordre Ringvej 57, 2600 Glostrup, Denmark; carinaslidsborg{at}hotmail.com

Abstract

Background To investigate whether neonatal hyperglycaemia in the first postnatal week is associated with treatment-demanding retinopathy of prematurity (ROP).

Methods This is a Danish national, retrospective, case–control study of premature infants (birth period 2003–2006). Three national registers were searched, and data were linked through a unique civil registration number. The study sample consisted of 106 cases each matched with two comparison infants. Matching criteria were gestational age (GA) at birth, ROP not registered and born at the same neonatal intensive care unit. Potential ‘new’ risk factors were analysed in a multivariate logistic regression model, while adjusted for previously recognised risk factors (ie, GA at birth, small for gestational age, multiple birth and male sex).

Results Hospital records of 310 preterm infants (106 treated; 204 comparison infants) were available. Nutrition in terms of energy (kcal/kg/week) and protein (g/kg/week) given to the preterm infants during the first postnatal week were statistically insignificant between the study groups (Mann-Whitney U test; p=0.165/p=0.163). Early postnatal weight gain between the two study groups was borderline significant (t-test; p=0.047). Hyperglycaemic events (indexed value) were statistically significantly different between the two study groups (Mann-Whitney U test; p<0.001). Hyperglycaemia was a statistically independent risk factor (OR: 1.022; 95% CI 1.002 to 1.042; p=0.031).

Conclusion An independent association was found between the occurrence of hyperglycaemic events during the first postnatal week and later development of treatment-demanding ROP, when adjusted for known risk factors.

  • Preterm birth, Retinopathy of Prematurity
  • Risk factors
  • Hyperglycemia.

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Footnotes

  • Contributors CS contributed towards the conception and design of the work; the acquisition, analysis and interpretation of data for the work; drafting the work; final approval of the version to be published and agreed to be accountable for all aspects of the work. LBJ contributed towards the acquisition; drafting the work; final approval of the version to be published and agreed to be accountable for all aspects of the work. SCR contributed towards acquisition of data for the work; drafting the work; final approval of the version to be published and agreed to be accountable for all aspects of the work. HCF contributed towards the conception and design of the work; drafting the work; final approval of the version to be published and agreed to be accountable for all aspects of the work. GG contributed towards the conception and design of the work; analysis and interpretation of data for the work; drafting the work; final approval of the version to be published and agreed to be accountable for all aspects of the work. MdlC contributed towards the conception and design of the work; analysis and interpretation of data for the work; drafting the work; final approval of the version to be published and agreed to be accountable for all aspects of the work.

  • Funding This work was supported by grants from Danish Eye Health Society, Bagenkop Nielsens Myopi- and Eye Foundation, Velux foundation, Aase and Ejnar Danielsens Foundation, Dagmar Marshalls Foundation, Direktør Jacob Madsen and Hustru Olga Madsens Foundation, P. A. Messerschmidt and Hustrus Foundation.

  • Competing interests None declared.

  • Patient consent Not obtained as patients were not directly involved.

  • Ethics approval This study was approved by the Danish Data Protection Agency.

  • Provenance and peer review Not commissioned; externally peer reviewed.

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