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Pterygia are indicators of an increased risk of developing cutaneous melanomas
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  • Published on:
    Big data, selection bias and clinical significance
    • Jingjing Shen, ophthalmologist 1. Zhongshan Hospital Affiliated to Fudan University 2. Center for Evidence-based Medicine, Fudan University
    • Other Contributors:
      • Minqian Shen, ophthalmologist
      • Yuanzhi Yuan, ophthalmologist

    Title Page

    Title:
    Letter to the Editor

    The article in question:
    Crewe JM, Threlfall T, Clark A, Sanfilippo PG, Mackey DA. Pterygia are indicators of an increased risk of developing cutaneous melanomas. Br J Ophthalmol 2017.

    Authors:
    Jingjing Shen
    Minqian Shen
    Yuanzhi Yuan

    Corresponding author:
    Yuanzhi Yuan

    Address:#180 Fenglin Rd., Department of Ophthalmology, Zhongshan Hospital Affiliated to Fudan University, Shanghai 200032, P.R. China
    Email: yuan.yuanzhi@zs.hospital.sh.cn
    Phone: +86-186 1688 1220 or +86-21-64041990 ext. 2684

    Dear Editor,

    We read with great interest the paper by Crewe et al.1 The authors showed that patients with pterygium had higher risk of cutaneous melanomas (CM) in a large retrospective matched-cohort study in Western Australia (WA), and suggested pterygium as an indicator for CM. The finding was interesting. However, we doubt the conclusion and its clinical relevance and public health significance.

    Compared to control group, patients with pterygium had a 20% or 24% increased risk of developing CM in terms of odds ratio(OR) or incidence rate ratio (IRR), respectively. The incidence rate difference(IRD), however, was only 27.7/100 000 person-years (PY) (Table 5., by subtracting the IR of the control group from that of the pterygium group, i.e. (186.5-158.8)/100 000 PY). The rate difference corres...

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    Conflict of Interest:
    None declared.