Article Text

PDF
Peripapillary vascular changes in radiation optic neuropathy: an optical coherence tomography angiography grading

Abstract

Aims To investigate peripapillary vascular changes secondary to radiation optic neuropathy (RON) using optical coherence tomography angiography (OCT-A) and to propose a clinical grading of RON based on OCT-A findings.

Methods Thirty-four patients affected by RON were consecutively included. Each patient underwent best corrected visual acuity measurement (ETDRS score) and OCT-A (Nidek RS-3000 Advance device, Nidek, Gamagori, Japan). The radial peripapillary capillary plexus (RPCP) and the entire peripapillary capillary bed (EPCB) were analysed. Quantitative analysis of the OCT-A images was performed using open-source available ImageJ software (National Institutes of Health, Bethesda, Maryland, USA). Qualitative analysis based on the proposed clinical grading (Grades 0–4) was also performed by two masked graders.

Results RON clinical (qualitative) classification based on RPCP correlated with the quantitative RPCP perfusion analysis (P=0.0001). RON clinical classification based on RPCP statistically correlated with ETDRS score (P=0.001). RON clinical classification based on EPCB also correlated with the quantitative EPCB perfusion analysis and ETDRS score (P=0.02 and P=0.01, respectively). Compared with the clinical classification based on EPCB, the qualitative classification based on RPCP reached a higher intergrader agreement (0.96 and 0.86, respectively).

Conclusion OCT-A can be used to detect RPCP abnormalities and to clinically classify RON with a high interexaminer agreement. The proposed clinical classification is supported by the quantitative analysis based on the use of specific images elaboration techniques and correlates with visual acuity of the examined eyes.

  • retina
  • imaging
  • optic nerve
  • neoplasia
  • diagnostic tests/investigation

Statistics from Altmetric.com

Footnotes

  • Contributors RP and EM were responsible for the study conception and design. LF, DL, ST, RLM, FL, SP, GM and EP were responsible for the data acquisition and analysis. All authors equally contributed ot the interpretation, drafting and revising of work, final approval and agreed to be accountable for all aspects of the work.

  • Funding The contribution of the Fondazione Bietti to this paper was supported by the Ministry of Health and Fondazione Roma.

  • Competing interests None declared.

  • Patient consent Obtained.

  • Ethics approval Institutional Review Board of University of Padova/Azienda Ospedaliera di Padova.

  • Provenance and peer review Not commissioned; internally peer reviewed.

Request permissions

If you wish to reuse any or all of this article please use the link below which will take you to the Copyright Clearance Center’s RightsLink service. You will be able to get a quick price and instant permission to reuse the content in many different ways.