124 e-Letters

published between 2014 and 2017

  • Classification Of Diabetic Macular Odema Using Ultra- Wide field angiography and implications for response to anti-VEGF therapy

    Dear Sir,
    We read the article "Classification of diabetic macular odema using ultra-widefield angiography and implications for response to anti-VEGF therapy" by Xue K, et al1 with great interest. The authors aimed to classify Diabetic macular odema [DMO] using ultra-widefield flourescein angiography [UWFA] and evaluate response to anti-vascular endothelial growth factor [anti-VEGF]. They concluded that UWFA facilitates detection of peripheral ishemia. DMO group with significant peripheral ishemia responded well to anti-VEGF therapy than other groups. We congratulate the author for their lightening study about subject and would like to make some contributions about study.
    The study did not mention the severity of diabetes of the patients enrolled in the study nor systemic comorbid conditions like glycemic control, systolic hypertension, protinuria1, which would alter the incidence of macular odema.2, 3
    The study selected patients with DMO who have been given subthreshold micropulse diode laser. As it was not mentioned in the study, we wonder if the study desires to see the response of anti-VEGF in non-resolving macular odema patients alone. Also, it was to our surprise why patients with Panretinal photocoagulation were not excluded from the study while classifying the patients into 3 groups .
    The classification of DMO into three groups was not clearly satisfying because there would be always a component of ishemia overlapping between t...

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  • Response to Thevi T comments

    Dear Sir
    Thanks for this notification
    1. Preoperative and postoperative characteristics for the CF group are shown in Table 2 (line 13)
    Answer: This was a typing error hoping if it will be corrected to: preoperative and postoperative characteristics for the AMG group are shown in Table 2
    2. The study does not mention about the location postoperatively. How will the site of the ulcer change from central to paracentral and vice versa?
    Answer: Eighteen from twenty patients in each group showed healing of the ulcer, and two cases in each group were sent for keratoplasty (from 4 to 8 days after intervention). So, there is no need to mention size of the ulcer. Regarding site of the ulcer; some paracentral ulcer are creeping and/or enlarging in size to involve the central part.
    Regarding site of the ulcer; some paracentral ulcer are creeping and/or enlarging in size to involve the central part.
    So the description of the ulcer will be changed from peripheral to central.
    There was no need to mention this as the ulcers healed.
    3. There is no mention about the complications studied. Descemetocele and perforations occurred preoperatively.
    Answer: Three cases with perforation and one case with descemetocele were referred to immediate keratoplasty, and other ulcers healed, so there were no complications to be mentioned. Regarding other complications in secondary outcome measures, there were no complications and this was mentio...

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  • Bilateral Descemet membrane detachment and Terrien’s marginal degeneration

    We read with interest the study by Odayappan et al regarding outcomes of air descemetopexy for Descemet membrane detachment (DMD). [1] It is interesting to note the lack of corneal pathology associated with DMD in their case series, and the discussion regarding the contribution of incision sites. We would like to raise the issue of peripheral corneal pathology as a contributing factor in DMD. Recently we had a complex case involving a 91-year-old with extensive Terrien’s marginal degeneration and corneal scarring, who underwent right cataract surgery. This was complicated by DMD and he had successful air descemetopexy within the first month. He then proceeded to have left cataract surgery, with a residual air bubble left in the anterior chamber, yet he still developed DMD. We scheduled surgery but he was unable to attend due to illness and hospital admission. When he was reviewed at 3 months post operatively, the DMD had reattached, with normalised pachymetry and visual acuity of 6/12 bilaterally.

    While we agree that air descemetopexy is an efficient treatment modality for DMD, our case highlights that other co-morbidities can influence management. As the anatomical and visual outcomes were similar in both eyes, our case raises the issue of lack of clear guidance in the literature regarding when to intervene in DMD and when to observe.

    Terrien’s marginal degeneration is a slowly progressive thinning of the peripheral cornea, with formation of a scarred gutte...

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  • Amniotic membrane graft to conjunctival flap in treatment of non-viral resistant infectious keratitis: a randomised clinical study

    Dear Editor,
    I read with interest the above randomised clinical study published by
    Abdulhalim et al in BrJ Ophthal 2015;99:59-63.
    The main outcome measures were location, size and depth of the lesion,
    epithelialisation time and persistence of infection. Secondary outcome
    measures include visual acuity and other complications.

    Table 1 states Demographic data and preoperative characteristics for
    conjunctival flap group.
    Table 2 states Demographic data and preoperative characteristics for
    amniotic transplant group.
    However in the narration in Results-it states preoperative and
    postoperative characteristics for the CF group are shown in Table 1 (line
    5) preoperative and postoperative characteristics for the CF group are
    shown in Table 1. preoperative and postoperative characteristics for the CF
    group are shown in Table 2 (line 13). This is very confusing.

    Table 3 shows a comparison of CF group and AMG. Here the preoperative and
    postoperative characteristics are all in one table.

    The main outcome measures were location. The study does not mention about
    the location postoperatively. How will the site of the ulcer change from
    central to paracentral and vice versa? There is no mention about the size
    and depth of the ulcer- which is also a parameter that was studied.There is
    no mention about the complications studied. Descematocoele and perforations...

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  • Higher posterior capsular rupture rates in male patients

    We read with great interest the study by Salowi and colleagues,[1] analysing risk factors for posterior capsular rupture (PCR) in over 150,000 cataract operations across Malaysia. Many of the significant risk factors were expected and well-recognised, such as junior surgeon or pseudoexfoliation. An interesting finding was increased PCR in males, with odd ratio 1.11 (95% confidence interval 1.04 to 1.17).

    Male gender has been found to be a risk factor for PCR in other large retrospective studies. The Cataract National Dataset of 55,567 cataract operations across 12 National Health Service Trusts in the UK found male gender to have an adjusted odds ratio of 1.28 (95% CI 1.13-1.45).[2] We recently reviewed 62,994 cataract operations performed at Moorfields, showing male gender as a significant risk for PCR, with OR 1.490 (95% CI 1.274–1.741).[3] This risk was similar to junior surgeon (OR 1.483) or prior intravitreal injection (OR 1.664), an increasingly acknowledged predictor of complicated surgery.

    The reasons for increased PCR in male patients is unclear. Males are significantly more likely to take tamsulosin, an alpha receptor blocker used in the treatment of benign prostatic hypertrophy. This can lead to poor pupillary dilation and intraoperative floppy iris syndrome (IFIS).[4] Although this can be effectively managed with intracameral phenylephrine, iris hooks or Malyugin ring, it remains a risk factor for PCR. Furthermore, males are more likely to be aff...

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  • LETTER TO EDITOR-Treatment patterns and medication adherence of patients with glaucoma in South Korea

    Dear sir/maam

    I whole heartedly appreciate the work conducted by Chan Yun Kim et al in studying the treatment patterns and medication adherence of patients with glaucoma in South Korea.This study concluded that medication non adherence was seen more commonly in males , increased daily number of administration and increase in the number of eyedrops. We have also conducted a similar study at our centre in North India and would like to share our results .Our results are in agreement to the work conducted by Chan Yun Kim stating that increased number of instillation and increased number of eyedrops contribute significantly to medication non adherence. However, in our study we also found that medication adherence varies in different severity grades of glaucoma with severe stages being significantly more adherent than mild to moderate stages of glaucoma.Additionally, there was no difference found in medication adherence among males or females.

    We again express our gratitude to the researcher in enlightening our minds regarding medication adherence in South Korean population.

  • Response: Non-traumatic corneal perforations: aetiology, treatment and outcomes

    Dear editor.

    We thank Sarmad et al. for their interest in our publication. Our study is a retrospective review of several variables regarding non-traumatic corneal perforations (1). In handling clinical records for a retrospective analysis, missing variables represent a common problem. In relation to the location of corneal perforation, information was not available in 25 eyes thus the number does not match. Hence, in consideration of this inevitable flaw we decided not to include the anatomical location of perforation into the model presented in the manuscript, therefore all the variables included in this statistical model had no missing values.

    Clinical treatment of corneal perforation is often complex and a single intervention may not address the patient full pathology, therefore more than one treatment is frequently used. (2) This explains the increased number of initial treatments in the first clinical intervention, one example of this scenario are the patients needing simultaneous tectonic penetrating keratoplasty to restore ocular integrity and concurrent amniotic membrane transplantation to aid in the control of ocular surface. (2)(3)

    These two situations might not be precise in our manuscript, but we take the opportunity of this letter to clarify them. However, that is unquestionably far from compromising the validity of the conclusions. Definitely, as any retrospective study, and as we mention in the discussion of our article, there are li...

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  • Reply

    We warmly thank Calugaru D and associates for their correspondence regarding our article entitled " Early response to ranibizumab predictive of functional outcome after dexamethasone for unresponsive diabetic macular oedema".1
    We agree with them about some of the challenges concerning our study. As we have acknowledged in the limitation section of our article, our study is limited by several biases, as its design was retrospective. In particular, patients selection and follow-up represented some of the major flaws in our study. We collected data about patients switched to dexamethasone for different reasons; some patients were treatment-naïve, other had already undergone treatments for diabetic macular edema (DME). No one disclosed any feature of chronic long-standing DME; all of them received prompt therapy after DME diagnosis.
    Some of them showed a good response to ranibizumab loading-dose, with satisfying reduction of macular thickness after the injections. Nevertheless, no patient disclosed a completely dry macula after the anti-vascular endothelial growth factor (VEGF) loading-dose.
    As far as it regards the final functional and anatomical gain at the end of the follow-up, the Authors state that the outcomes of this series were unsatisfactory. However, in the non-responders group, despite initial poor results, the best-corrected visual acuity (BCVA) had improved significantly (p<0.05) and clinically (> 5 letters), as highlighted in the...

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  • Re: Non-traumatic corneal perforations: aetiology, treatment and outcomes

    Dear Editor,
    We read your article titled- Non-traumatic corneal perforations: aetiology, treatment and outcomes: with great interest. Corneal perforation is an acute ophthalmic emergency. This review describes the aetiology, plausible location and the multiple ways to approach the management of this condition in a very a systematic manner.
    We do appreciate the organised mode of stratification and care of non- traumatic corneal perforation presented in the article. However, although the results are interesting, we feel that caution should be exercised when drawing conclusions from this data.
    Initially, in results there are 127 eyes of 116 patients under the review. However, while describing the anatomical location of the perforation, only 102 eyes have been accounted for, with no records for the remaining 25 eyes. This would change the calculated p value significantly.
    Similarly, where the initial treatments for perforations were being reviewed 133 eyes were mentioned as treated, thus including six extra unaccounted for eyes to the total. This would seriously jeopardise the authenticity of the calculated results.

    Hence, there appears to be serious doubts regarding the validity of the conclusions of this review. A clearer and more detailed explanation or a recalculation of the results is warranted in this regard.

  • Response to: Response to "Preoperative aqueous humour flare values do not predict proliferative vitreoretinopathy in patients with rhegmatogenous retinal detachment"

    Thank you for your interest in our publication entitled "Preoperative aqueous humour flare values do not predict proliferative vitreoretinopathy in patients with rhegmatogenous retinal detachment".

    As per request, we would like to provide more details on our protocol.

    As described in our discussion, centre 1 used the mean of ten correct measurements making sure these measurements did not differ more than 2 standard deviations from each other. In centre 2, seven correct measurements were recorded of which the highest and lowest value were discarded leaving an average of five measurements. A correct measurement meant that the background readings did not differ more than 15% (indicated by the code ‘BG’ on the output) and that single “cell/C” measurements were replaced by an additional measurement. In addition, measurements with a small signal to noise ratio (indicated by the code ‘s/n’) were avoided as much as possible. However, with low flare values this was not always feasible. The flare meters were located in a room with blinds (centre 1) and a room without windows (centre 2); computer screens and lights were turned off during measurements. Both flare meters were calibrated monthly to assure correct readings. We therefore believe that the included mean values are artefact free.

    Despite the exclusion of patients with additional conditions such as AMD, CRVO and preoperative PVR grade C or higher, we did end up with patients with a preopera...

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