eLetters

127 e-Letters

published between 2014 and 2017

  • Re:Reproducibility of aberrometry-based intraoperative refraction during cataract surgery, Statistical issues
    Jan O Huelle

    Dear Sirs, We are grateful to Sabour and Ghassemi for their interest in our recent article[1]. In our understanding, they query why we did not use intra class correlation (ICC) as a measure for precision. Our test-retest reliability (absolute agreement ICC) is derived from the maximum likelihood (LM) estimates of the one-way random effects model of the form: yij...

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  • An additional explanation for azithromycin's efficacy in treating meibomian gland dysfunction
    Yang Liu

    We would like to congratulate Dr. Kashkouli et al for their recently published paper "Oral azithromycin versus doxycycline in meibomian gland dysfunction: a randomized double masked open label clinical trial". The authors found that azithromycin induced a significantly better overall clinical response than doxycycline, and attributed this effect to the antibacterial and anti-inflammatory effects of azithromycin. However,...

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  • Reporting of harms in clinical trials: why do we continue to fail?
    Imran Mahmud

    O'Day and colleagues describe in their recent paper the inadequate reporting of harm in randomized controlled trials of intra-vitreal therapies for diabetic macular oedema(O'Day et al., 2014). At first glance, the results are alarming. An average of only six recommendations of the 2004 CONSORT guidelines extension covering harms were met. Ophthalmologists are not alone in their inadequate reporting, however. Several oth...

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  • Perceptual learning in visual acuity and contrast sensitivity: continuous improvement or discovery effect?
    Michael Bach

    In their paper "Repetitive tests of visual function improved visual acuity in young subjects" Otto and Michelson [1] assessed effects of practice on visual acuity, using the Freiburg Visual Acuity Test "FrACT" developed by one of us [2,3]. At first glance they seem to confirm our findings [4], which showed a marked increase of visual acuity after visual training, more than 0.1 logMAR. At closer inspection, discrepancies...

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  • Reproducibility of aberrometry-based intraoperative refraction during cataract surgery, Statistical issues
    Siamak Sabour

    We were interested to read the paper by Huelle JO and colleagues published in the May 2014 issue of BJO. The authors aimed to provide the first clinical data in determining the feasibility, quality and precision of intraoperative wavefront aberrometry (IWA)-based refraction in patients with cataract. Precision (reproducibility) and measurement quality was evaluated by the 'limits of agreement' approach, regression analysi...

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  • FRACTURED OZURDEX IMPLANT DURING THE PROCEDURE
    Gonzaga Garay-Aramburu

    In the recent article published in British Journal of Ophthalmology, Agrawal et al1

    reported two cases of desegmentation of Ozurdex implant in vitreous cavity. In this report, the authors comment that Allergan confirmed that fractured implants in the applicator have not been found to date during the quality control process. We recently reported2

    also two cases of implant fragmentation in response t...

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  • Is the term dry eye a misnomer?
    W LESLIE ALEXANDER

    As an ophthalmologist for many years, I continue to find the diagnosis of dry eye difficult unless it is severe. I have spoken to colleagues who have the same experience. As detailed in this paper there are many things going on in the pathophysiology of which dryness may be one. Can I suggest it might be helpful to our understanding and approach to sore eyes, to be less dogmatic about attributing dryness as the reason f...

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