eLetters

47 e-Letters

published between 2011 and 2014

  • Switching anti-VEGFs in Tachyphylaxis
    Kopal Mithal

    Dear Editor,

    We read the article 'Bevacizumab and ranibizumab tachyphylaxis in the treatment of choroidal neovascularisation' with interest. We congratulate the authors for trying to establish the efficacy of a promising treatment strategy for Tachyphylaxis to Anti-VEGF drugs in Exudative AMD. We agree with the authors that this could be a useful option in patients who develop tachyphylaxis. However, there are s...

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  • Efficacy of Silicone Punctal Plugs in Children
    Mohammad J Ali

    We read with great interest the article by Mataftsi A et al.1 We congratulate the authors for providing insights into the use of punctal plugs in children. We would like to articulate a few of our observations. In seven cases where a secondary procedure was undertaken like a subconjunctival steroid injection or placement of contact lens, we believe these would be confounding...

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  • Potential Confounding factors
    Jignesh K Ved

    I would like to congratulate the authors for this wonderful effort, which throws some light on some of the time trends in the therapeutic area. However, while interpreting long term observational studies, some of the potential sources of bias should be kept in mind. One such potential confounding factor, is the observation of the end- points for Latanoprost, in the two distinct time-periods. The results for both the end-po...

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  • e-Iatrogenesis - the need for "error wisdom"
    John E A. Somner

    Simon Kelly is to be congratulated for his work to increase awareness of patient safety issues in ophthalmology. His studies analysing safety incidents recorded in the NPSA database have led to descriptions of incidents related to intravitreal injections and wrong lens insertion and suggestions on how to improve patient safety. Many of the patient safety incidents analysed resulted from poor documentation described in the...

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  • Response
    Malik Y Kahook

    We would like to thank Zaidi et al. for their interest in our publication titled, "Sustained elevation of intraocular pressure after intravitreal injections of anti-VEGF agents." [1] As stated in our publication, we believe anti-VEGF agents revolutionized the treatment of ocular neovascular disease and their overall safety profile is excellent. The points by Zaidi et al. are valid and we take this opportunity to expand...

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  • respond
    Vannarut Satitpitakul

    In your September 2010 issue, I read with interest the article about amblyopia by D J Hwang.1 The group has also previously published a similar article in Korean Journal of Ophthalmology 2 but it was not mentioned in the references. Both articles included their participants from the same hospital since 2000 and the eligibility criteria were nearly identical. I was wondering if both articles share the same group of parti...

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  • Treatments for macular degeneration: summarising evidence using network meta-analysis
    Valeria Fadda

    Treatments for age-related macular degeneration (AMD) are lively being debated. One controversy is that all randomized controlled studies published thus far have used placebo or verteporfin in the control group [1,2]; hence, direct head-to-head comparisons between the newest active agents are lacking. The only randomised trial comparing ranibizumab vs bevacizumab (CATT study [3]) is still ongoing and its results are...

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  • Letter response to: The utility of relative afferent pupillary defect as a screening tool for glaucoma: prospective examination of a large population-based study in a south Indian population
    George Spaeth

    Dear Editor:

    The article by Hennessy and co-authors is important and interesting, and the last three words of the abstract are essential (The utility of relative afferent pupillary defect as a screening tool for glaucoma: prospective examination of a large population-based study in a south Indian population. BJO Online First, February 24, 2011, DOI: 10.1136/BJO. 2010.194217). Their conclusion is, "The authors...

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  • Author Response Re: "Need to further investigate the efficacy of valproic acid therapy in retinal degenerative disorders" letter
    Radouil Tzekov

    Dear Editor,

    We appreciate the interest of Dr. Kahn and Dr. Philip [1] in our paper describing pilot results from a retrospective study in patients with retinitis pigmentosa (RP) treated with valproic acid (VPA) [2], and we would like to comment on the points raised by them.

    Length of treatment. As mentioned in our recent reply to another letter regarding the same article [3], the length of treatment...

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  • Effectiveness of ranibizumab for neovascular age-related macular degeneration using clinician-determined retreatment strategy.
    Gerassimos Lascaratos

    We read with great interest the article by Kumar et al. We have audited our 1-year results using a slightly different clinical model: a nurse-led optical coherence tomography (OCT)-guided macula service.

    Following wet AMD diagnosis in the consultant-led macula clinic, three consecutive monthly ranibizumab injections are administered. Thereafter, patients are reviewed 4-6 weekly in the nurse-led clinic for 2 visi...

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