eLetters

575 e-Letters

  • Characteristics and quantification of vascular changes in macular telangiectasia type 2 on optical coherence tomography angiography
    Chun Ding

    EDITOR:

    With great interest,We have read the article by Chidambara1 and partners on characteristics and quantification of vascular changes in macular telangiectasia type 2( MacTel 2) on optical coherence tomography angiography(OCTA).The authors concluded that OCTA helps understand the pathology and disease progression better in MacTel 2.We commend their interesting and important work on this subject.However, w...

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  • Cigarette smoke extract-mediated oxidative stress and fibrotic-related genes expression may contribute to poor response to steroids therapy in Graves' ophthalmopathy
    Yu-Fan Chang

    We read with great interest the article entitled "Smoking was associated with poor response to intravenous steroids therapy in Graves' ophthalmopathy" by Xing et al [1]. Cigarette smoking is known to be the most important risk factor for the development or deterioration of GO, and it is associated with poor response to treatment for GO. However, the exact mechanisms which prove deleterious effect of cigarette smoking on GO rem...

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  • Increased expression of connective tissue growth factor play a role in the pathogenesis of thyroid eye disease
    Yun-Chun Peng

    We read with great interest the article entitled "Pathogenesis of thyroid eye disease: review and update on molecular mechanisms" by Khong et al [1]. We would like to contribute to the article with our novel findings.

    In our previous study, we first demonstrated the up-regulation of mRNA and protein expression of fibrosis-related genes including fibronectin, apolipoprotein J and connective tissue growth factor...

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  • Optic disc edema in astronauts following long-duration space flight
    Thomas H. Mader

    Optic disc edema in astronauts following long-duration space flight

    We commend Morgan and colleagues for their discussion of optic disc changes during and after long-duration space flight (LDSF). 1 They note that astronauts after LDSF have developed clinical features (disc edema, globe flattening) similar to those of idiopathic intracranial hypertension (IIH) that may persist for many months post flight and sugg...

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  • RE: Global variations and time trends in the prevalence of primary open angle glaucoma (POAG): a systematic review and meta-analysis. Kapetanakis, et al. 100:1 86-93 doi:10.1136/bjophthalmol-2015-307223
    Alicja R Rudnicka

    Dear Editor,

    We thank Cheng and Tham for their interest in our systematic review of global variations and time trends in primary open angle glaucoma (POAG).[1] The comments raise some important issues relating to the assimilation of evidence from observational studies, particularly in summarising estimates of chronic disease prevalence.

    Cheng and Tham have questioned our inclusive approach, which resu...

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  • Re: Global variations and time trends in the prevalence of primary open-angle glaucoma: a systemic review and meta-analysis
    Ching-Yu Cheng

    Dear Editor,

    We read with interest the article by Kapetanakis et al.[1] The authors presented a systemic review of published population-based surveys to provide estimates of global and regional prevalence of primary open- angle glaucoma (POAG). The authors claimed that this review provided the most precise estimates of POAG prevalence thus far, as they adopted a more "inclusive" approach, compared to previous re...

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  • Real life visual improvements with anti vascular endothelial growth factor treatment for wet age-related macular degeneration - Absolute or relative?
    Balasubramanian Ramasamy

    Dear Editor

    We congratulate Holz et al.1 on their most important contribution to anti-vascular endothelial growth factor therapy in neovascular age-related macular degeneration (n-AMD). We think it is important to note that their main finding "visual acuity improved until about day 120; thereafter visual acuity changes were not maintained" does not contradict the findings of the MARINA2 [Ranibizumab Vs sham in...

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  • Amniotic membrane graft to conjunctival flap in treatment of non-viral resistant infectious keratitis: a randomised clinical study
    Abdullah ILHAN

    Dear Editor; We have read the article entitled "Amniotic membrane graft to conjunctival flap in treatment of non-viral resistant infectious keratitis: a randomised clinical study" by Abdulhalim et al. with interest.1 The authors compare the results of bipedicle conjunctival flap and cryopreserved amniotic membrane graft in the treatment of non-viral infectious keratitis resistant to medical treatment. We want to express...

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  • Response to " Recovery of photoreceptor inner and outer segment layer thickness after reattachment of rhegmatogenous retinal detachment"
    Roshan T

    We read with great interest the study" Recovery of photoreceptor inner and outer segment layer thickness after reattachment of rhegmatogenous retinal detachment" by Terauchi G, et al.[1] Authors concluded that thickness of inner segment layer (20.4 +/- 5.0 microns) at one month after surgery was significantly less than fellow eye (28.9 =/- 2.9 microns). However, we know that the axial resolution of Spectral Domain(SD)...

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  • Genetic Testing for Chromosomal Aberration in Choroidal Melanoma
    Kakarla V. Chalam

    The authors have investigated the and compared the chromosome 3 aberrations of Choroidal melanoma (CM) as determined by multiplex ligation probe amplification (MLPA) or microsatellite analysis (MSA)in intra ocular tumor biopsies with those results obtained from subsequent endoresection/enucleation of the same Choroidal melanoma. However few points need clarification from the authors: 1. Since the investigators used few ma...

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