Presumed macular choroidal watershed vascular filling, choroidal neovascularization, and systemic vascular disease in patients with age-related macular degeneration*
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Cited by (91)
Pathogenesis of myopic choroidal neovascularization: A systematic review and meta-analysis
2023, Survey of OphthalmologyThe VEGF paradox: Does diabetic retinopathy protect from age related macular degeneration?
2017, Medical HypothesesCitation Excerpt :In this context, elevated VEGF levels stimulate the proliferation of new blood vessels from the choriocapillaris closest to the stimulation site. Neovessels mainly occur in hypoperfused areas [16]. This process explains how a dry form becomes a wet or exudative form.
Hypothesis: Watershed zones in the human eye are a key for understanding glaucomatous retinal damage
2017, Medical HypothesesCitation Excerpt :The specific WSZs of the peripheral choroid were described later [10]. Subsequently, choroidal WSZs were discussed in the context of age-related macular degeneration [11,12], normal-tension glaucoma [13], ischemic optic neuropathy [14,15], and polypoidal vasculopathy [16,17]. The WSZs of the retina and choroid are not true WSZs as found in the brain and colon.
A Revised Hemodynamic Theory of Age-Related Macular Degeneration
2016, Trends in Molecular MedicineDelayed patchy choroidal filling in the comparison of age-related macular degeneration treatments trials (CATT)
2014, American Journal of OphthalmologyMetabolic physiology in age related macular degeneration
2011, Progress in Retinal and Eye ResearchCitation Excerpt :Similar findings were reported by Piguet et al. (1992). Patients with AMD were more likely to have choroidal watershed filling defects during fluorescein (Chen et al., 1992) and indocyanine green angiography (Pauleikhoff et al., 1999; Ross et al., 1998; Ryan et al., 2001) than were controls, although the controls were not matched on important factors such as hypertension (Pauleikhoff et al., 1999; Ross et al., 1998). Metelitsina et al. studied choroidal blood flow with a laser Doppler flowmeter in patients with AMD and found that the development of choroidal neovascularization and visual loss is associated with lower choroidal circulatory parameters at baseline.
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This work was supported by the Foundation for Retina Research, New Orleans, Louisiana. Presented in part at the Twentieth Annual Meeting of the Macula Society, Florence, Italy, June 18–21, 1997, and the Fifteenth Annual Meeting of the Vitreous Society, New Orleans, Louisiana, September 17–21, 1997.
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