Elsevier

Survey of Ophthalmology

Volume 39, Issue 6, May–June 1995, Pages 429-450
Survey of Ophthalmology

Ocular surface squamous neoplasia*

https://doi.org/10.1016/S0039-6257(05)80054-2Get rights and content

Abstract

Ocular surface squamous neoplasia presents as a spectrum from simple dysplasia to carcinoma in situ to invasive squamous cell carcinoma involving the conjunctiva as well as the cornea. It is a distinct clinical entity, although it has been known by a variety of different names thorughout the literature. Most commonly it arises in the limbal region, occurring particularly in elderly males who have lived in geographic areas exposed to high levels of ultraviolet-B radiation. Symptoms range from none to severe pain and visual loss. The development of preoperative diagnostic techniques, such as impression cytology, are of value in clinical decision making and follow-up management. Simple excision with adequate margins is currently the best established form of treatment despite trials of other modalities. The course of this disease may be evanescent, but is more frequently slowly progressive and may require exenteration and occasionally may lead to death.

References (179)

  • ErbakanS et al.

    Bowen's disease: Report of two cases

    Am J Ophthalmol

    (1963)
  • ErieJC et al.

    Conjunctival and corneal intraepithelial and invasive neoplasia

    Ophthalmology

    (1986)
  • EstermanB et al.

    Intra-epithelial epitheliomas of cornea and conjunctiva (Bowen's disease)

    Am J Ophthalmol

    (1947)
  • FarrisHE et al.

    Cyrosurgical treatment of ocular squamous cell carcinoma of the cattle

    J Am Vet Med Assoc

    (1976)
  • FreedmanJ et al.

    Surgical management and histopathology of invasive tumours of the cornea

    Br J Ophthalmol

    (1979)
  • GasterlandDE et al.

    Ocular involvement in xeroderma pigmentosum

    Ophthalmology

    (1982)
  • GlassonWJ et al.

    Cinicopathologic case report: invasive squamous cell carcinoma of the conjunctiva

    Arch Ophthalmol

    (1995)
  • GreavesDP

    Bowen's disease of the cornea

    Trans Ophthalmol Soc UK

    (1955)
  • KenyonKR et al.

    Limbal autograft transplantation for ocular surface disorders

    Ophthalmology

    (1989)
  • KimuraSJ et al.

    The cytology of external ocular disease

    Am J Ophthalmol

    (1955)
  • KinoshitaS et al.

    Limbal epithelium in ocular surface wound healing

    Invest Ophthalmol Vis Sci

    (1982)
  • LandoltE

    Zur Dyskerstose des Hornhautepithels

    Klin Monatsbl Augenheilkd

    (1978)
  • LennartA et al.

    Bowen's disease of the cornea and conjunctiva

    Acta Ophthalmol

    (1961)
  • LewHR et al.

    Variations in managements of adnexal tumors

    Aust NZ J Ophthalmol

    (1985)
  • LiWW et al.

    Intraocular invasion by papillary squamous cell carcinoma of the conjunctiva

    Am J Ophthalmol

    (1980)
  • LindenmuthKA et al.

    Invasive squamous cell carcinoma of the conjunctiva presenting as necrotizing scleritis with scleral perforation and uveal prolapse

    Surv Ophthalmol

    (1988)
  • LugossyG

    Precancerous conditions of the bulbar conjunctiva

    Am J Ophthalmol

    (1956)
  • LommatzschP

    Beta-ray treatment of malignant epithelial tumors of the conjunctiva

    Am J Ophthalmol

    (1976)
  • McDonnellJM et al.

    Demonstration of papillomavirus capsid antigen in human conjunctival neoplasia

    Arch Ophthalmol

    (1986)
  • McDonnellJM et al.

    Human papillomavirus DNA in tissues and ocular surface swabs of patients with conjunctival epithelial neoplasia

    J Invest Ophthalmol Vis Sci

    (1992)
  • AngervallL et al.

    Bowen's disease of the cornea and conjunctiva

    Acta Ophthalmol

    (1961)
  • AjaiyeobaIA et al.

    Tumours of the eye and orbit in Ibadan

    East Afr Med J

    (1992)
  • AwanKJ

    Intraepithelial epithelioma (Bowen's Disease) of the conjunctiva and chronic lymphocytic leukemia

    Ann Ophthalmol

    (1978)
  • BartleyGB et al.

    Orbital exenteration at the Mayo Clinic, 1967–1986

    Ophthalmology

    (1989)
  • BirgeHL

    Cancer of the eyelids. 1. Basal cell and mixed basal cell and squamous cell epithelioma

    Arch Ophthalmol

    (1938)
  • BlodiFC

    Squamous cell carcinoma of the conjunctiva

    Doc Ophthalmol

    (1973)
  • BowenJT

    Precancerous dermatoses: a study of two cases of chronic atypical epithelial proliferation

    J Cut Dis

    (1912)
  • BrownHH et al.

    Keratinizing corneal intraepithelial neoplasia

    Cornea

    (1989)
  • CarrollJM et al.

    A classification of limbal epitheliomas

    Arch Ophthalmol

    (1965)
  • ChaSB et al.

    Squamous cell carcinoma of the conjunctiva

    Int Ophthalmol Clin

    (1993)
  • CharDH et al.

    Resection of intraocular squamous cell carcinoma

    Br J Ophthalmol

    (1992)
  • ChassardJL et al.

    Contact X-ray therapy of limbus cornae squamous cell carcinomas. A report of 50 observations

    J Eur Radiother

    (1989)
  • ClearAS et al.

    Solar keratosis, pterygium and squamous cell carcinoma of the conjunctiva in Malawi

    Br J Ophthalmol

    (1979)
  • Chilova-AtanassovaB

    On the etiopathogenesis of malignant epithelial epibulbar tumours

    Folia Med

    (1990)
  • CohenBH et al.

    Spindle cell carcinoma of the conjunctiva

    Arch Ophthalmol

    (1980)
  • ContinoA

    Neue Beobachtungen unter Untersuchungen uber die Papillome des Limbus und der Hornhaut

    Arch Augenheilkunde

    (1911)
  • CoopHV

    Squamous cell carcinoma of the conjunctiva: case presentation and treatment

    Aust NZ J Ophthalmol

    (1987)
  • CruessAF et al.

    Corneal epithelial dysplasia and carcinoma in situ

    Can J Ophthalmol

    (1981)
  • DanopoulosED et al.

    Effects of urea treatment in malignancies of the conjunctiva and cornea

    Ophthalmologica

    (1979)
  • DaoudEH et al.

    Conjunctival carcinoma in Northern Sudan

    Sudan Med J

    (1970)
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    *

    Supported in part by the Queensland Cancer Fund, the University of Queensland, the Prevent Blindness Foundation and the Princess Alexandra Hospital.

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