Regular articleOptical coherence tomography measurement of macular and nerve fiber layer thickness in normal and glaucomatous human eyes☆
Section snippets
Materials and methods
A total of 367 subjects (534 eyes) examined between October 1998 and July 2000 at the New England Eye Center, Boston, Massachusetts, were enrolled in this cross-sectional study after informed consent approved by the New England Medical Center Human Investigation Review Committee.
All subjects underwent a thorough ophthalmologic examination. This consisted of the following: medical history (including ocular and family histories), visual acuity, refraction, intraocular pressure (IOP) measurement,
Subject basic characteristics
We performed peripapillary NFL and macula scans using the prototype OCT unit on 534 eyes of 367 subjects. A subset of subjects underwent peripapillary NFL (95 eyes of 61 subjects) and macular (126 eyes of 81 subjects) scanning with the commercial OCT unit on the same day as their prototype OCT scan. Demographic data are summarized in Table 1.
Effects of age, gender, and race among normal eyes
There was an effect of age on mean macular thickness. When measurements were performed with the prototype OCT unit, for which there was a larger
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Joel S. Schuman and Gadi Wollstein shared equal parts in the preparation of the manuscript.