Original articleEfficacy of Different Intraocular Lens Materials and Optic Edge Designs in Preventing Posterior Capsular Opacification: A Meta-Analysis
Section snippets
Methods
We followed the widely accepted methodologic recommendations in the present meta-analysis, which was performed according to a predetermined protocol.8, 9, 10 The main outcome measures included the rates of PCO and Nd:YAG laser capsulotomy.
Results
Twenty-nine potentially relevant publications were identified through the literature search.4, 5, 6, 7, 13, 14, 15, 16, 17, 18, 19, 20, 21, 22, 23, 24, 25, 26, 27, 28, 29, 30, 31, 32, 33, 34, 35, 36, 37 Among these, 23 randomized controlled trials met our criteria and were included in the present meta-analysis, with 14 that compared different biomaterials,4, 5, 19, 20, 21, 22, 23, 24, 25, 26, 27, 28, 29, 30 seven that compared different optic edge designs,6, 7, 31, 32, 33, 34, 35 and two that
Discussion
Posterior capsule opacification remains the most common cause of visual failure after successful cataract surgery. It is well known that PCO is caused by migration and proliferation of the residual lens epithelial cells (LECs) onto the central region of the posterior capsule.38 If the LECs could be removed completely, we would most likely avoid PCO. Unfortunately, complete surgical removal is impossible at present. Consequently, there is considerable interest in better ways to prevent this
Jin-Wei Cheng, MD, has been a physician at the Department of Ophthalmology, Changzheng Hospital, Second Military Medical University, since 2005. Dr Cheng has taught ophthalmology for medical students at the Second Military Medical University, since 2003. He has won the “the Medical Science Prize of Second Military Medical University” in 2005 and “the Science & Technology Prize of Shanghai Municipal Government”, in 2006. Dr Cheng’s research interests include cataract surgery, glaucoma surgery,
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2020, European Journal of Pharmaceutics and BiopharmaceuticsCitation Excerpt :Furthermore, they undergo epithelial to mesenchymal transformation resulting in a more fibroblastic phenotype which leads to contraction of the posterior capsule causing capsular wrinkling with increasing light scattering and a reduction in visual acuity [3–5]. Established risk factors are age, gender, dry eye disease, glaucoma, uveitis, age-related macular degeneration, hyperlipidemia [6], diabetic and inflammatory comorbidity [7], intraocular lens (IOL) design and material [8,9], surgical technique and surgeon experience [10]. Although IOL design (sharp-edge [11]), materials and surgical techniques have been significantly improved over the years [12], over long-term observation, PCO incidence remains frequent, and has to be treated by neodymium-doped yttrium aluminum garnet (Nd:YAG or Nd:Y3Al5O12) laser capsulotomy [13,14].
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Jin-Wei Cheng, MD, has been a physician at the Department of Ophthalmology, Changzheng Hospital, Second Military Medical University, since 2005. Dr Cheng has taught ophthalmology for medical students at the Second Military Medical University, since 2003. He has won the “the Medical Science Prize of Second Military Medical University” in 2005 and “the Science & Technology Prize of Shanghai Municipal Government”, in 2006. Dr Cheng’s research interests include cataract surgery, glaucoma surgery, and orbital surgery.
Rui-Li Wei, MD, a Professor of Ophthalmology, is the head of the Department of Ophthalmology, Changzheng Hospital, Second Military Medical University. Dr Wei is listed as a member of the editorial boards of the Chinese Journal of Practical Ophthalmology, the Chinese Journal of Optometry & Ophthalmology, and the Chinese Journal of Cancer Prevention and Treatment. He is also the committee secretary of the Shanghai Association of Ophthalmology. Dr Wei’s research interests include cataract surgery, after-cataract prevention, glaucoma surgery, and orbital surgery.
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