Original articleComparison of macular and peripapillary measurements for the detection of glaucoma: An Optical Coherence Tomography study
Section snippets
Subjects
One hundred thirty-three Hong Kong Chinese including 46 normal subjects, 48 glaucoma suspects, and 39 glaucoma patients examined during the period from October 2003 to February 2004 in the Department of Ophthalmology, Caritas Medical Center, who met the inclusion criteria of the study, were included. Caritas Medical Centre is the ophthalmic referral center in the Hong Kong Hospital Authority Kowloon West Cluster, serving a population size of approximately 1.2 million. The study was conducted in
Results
A total of 133 eyes from 133 subjects was included in the study. Only 1 eye was chosen in random in each subject, and each individual was assigned to 1 of the 3 diagnostic groups. Table 1 shows the demographics of the subjects. With regard to age, gender, and refractive error, there were no significant differences among the groups. For the mean deviation and the pattern standard deviation in the visual field results, significant differences were found between glaucoma and normal groups (P
Discussion
Numerous experimental and clinical studies have demonstrated that the retinal NFL becomes atrophic in glaucoma.13, 14, 15 Damages to the retinal NFL and the optic disc frequently precede visual field loss. Most modern imaging devices, including confocal scanning laser ophthalmoscopy, scanning laser polarimetry, and optical coherence tomography (OCT), are noninvasive techniques designed to target on the optic nerve head for scanning. The advantages of OCT have been recognized as being unaffected
References (27)
- et al.
Quantitative detection of glaucomatous damage at the posterior pole by retinal thickness mappingA pilot study
Ophthalmology
(1998) - et al.
Reduction of posterior pole retinal thickness in glaucoma detected using the Retinal Thickness Analyzer
Ophthalmology
(2004) - et al.
Analysis of macular volume in normal and glaucomatous eyes using optical coherence tomography
Am J Ophthalmol
(2003) - et al.
Heidelberg retina tomography and optical coherence tomography in normal, ocular-hypertensive, and glaucomatous eyes
Ophthalmology
(1999) - et al.
Reliability of nerve fiber layer thickness measurements using optical coherence tomography in normal and glaucomatous eyes
Ophthalmology
(2003) - et al.
Optical coherence tomography measurement of macular and nerve fiber layer thickness in normal and glaucomatous human eyes
Ophthalmology
(2003) - et al.
Optical coherence tomography to detect and manage retinal disease and glaucoma
Am J Ophthalmol
(2004) - et al.
Evaluation of the glaucomatous damage on retinal nerve fiber layer thickness measured by optical coherence tomography
Am J Ophthalmol
(2003) - et al.
A comparison of optical coherence tomography and retinal nerve fiber layer photography for detection of nerve fiber layer damage in glaucoma
Ophthalmology
(2000) - et al.
Retinal nerve fiber layer analysis: relationship between optical coherence tomography and red-free photography
Am J Ophthalmol
(2002)
Correlation between optical coherence tomography, pattern electroretinogram, and visual evoked potentials in open-angle glaucoma patients
Ophthalmology
Retinal nerve fiber layer thickness measured with optical coherence tomography is related to visual function in glaucomatous eyes
Ophthalmology
Study of central retinal ganglion cell loss in experimental glaucoma in monkey eyes
J Glaucoma
Cited by (273)
Macular imaging with optical coherence tomography in glaucoma
2020, Survey of OphthalmologyCitation Excerpt :Studies on detection of glaucoma based on Stratus OCT mainly focused on total macular thickness measurements. The AUCs for discriminating between glaucoma patients and normal subjects with total macular thickness ranged from 0.53 to 0.64 for glaucoma suspects/preperimetric glaucoma eyes119,234 and 0.68-0.88 in perimetric glaucoma.119,234,257,402 The highest AUC was observed in the temporal outer macular region on the EDTRS grid.255,390
Structure-function relationship and diagnostic value of macular ganglion cell complex measurement using Fourier-domain OCT in glaucoma
2024, Indian Journal of OphthalmologyPrediction of Central Visual Field Measures From Macular OCT Volume Scans With Deep Learning
2023, Translational Vision Science and Technology
Manuscript no. 240318.
The authors have no proprietary interest in the development or marketing of any product mentioned in the article.