Original articleRisk Factors for the Incidence of Advanced Age-Related Macular Degeneration in the Age-Related Eye Disease Study (AREDS): AREDS report no. 19
Section snippets
Study Population
Details of the study design and methods, presented elsewhere,18 are briefly summarized here. Eleven retinal specialty clinics enrolled 4757 participants in the AREDS from 1992 through 1998. Participants were 55 to 80 years old at enrollment and had best-corrected visual acuity (BCVA) of 20/32 or better in at least one eye (the study eye[s]). Media had to be sufficiently clear to obtain adequate quality stereoscopic fundus photographs of the macula in all study eyes. Visual acuity (VA) was
Results
In Table 1, baseline risk factors are categorized for the bilateral drusen participants and the participants with unilateral advanced AMD. For the 2506 participants in the bilateral drusen group, the mean age was 68.5 years (standard deviation [SD], 5.0). For the 788 participants with unilateral advanced AMD, the mean age was 70.3 years (SD, 5.2). Mean follow-up time for all participants was 6.3 years. More females than males participated, and they were predominantly (96%–98%) white. Relative
Discussion
Results of these analyses provide information regarding associations of demographic, behavioral, medical, and non-AMD ocular factors with the incidence of neovascular AMD and central GA among participants with preexisting signs of AMD. Strengths include the standardized protocols for obtaining data, standardized definitions for risk exposure, photographic assessment of the outcomes and retinal risk categories, the large size of the cohort (n = 3394) at risk for these conditions, and the
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Manuscript no. 240543.
The study was supported by contracts from the National Eye Institute, Bethesda, Maryland.
The writing team and the members of the AREDS Research Group have no relevant financial interest in the article.
Writing team: Traci E. Clemons, PhD (The EMMES Corporation, Rockville, Maryland), Roy C. Milton, PhD (The EMMES Corporation), Ronald Klein, MD (University of Wisconsin, Madison, Wisconsin), Johanna M. Seddon, MD (Massachusetts Eye and Ear Infirmary, Boston, Massachusetts), Frederick L. Ferris III, MD (National Eye Institute, Bethesda, Maryland).
E-mail: [email protected].
Reprint requests to AREDS Coordinating Center, The EMMES Corporation, 701 North Washington Street, Suite 700, Rockville, MD 20850-1707. E-mail: [email protected].
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A complete list of the AREDS Research Group is found in Ref. 52.