Original articleLong-term Follow-up of Conjunctival and Corneal Intraepithelial Neoplasia Treated with Topical Interferon Alfa-2b
Section snippets
Subjects and Methods
Twenty-eight eyes of 26 patients with CIN, 15 eyes treated in a private practice (BAS) and 13 eyes treated at the Bascom Palmer Eye Institute (CLK), were included in this study. Twenty-one of the 28 lesions were diagnosed histologically. Clinical diagnosis8, 9 of the other 7 lesions was made by an ophthalmologist who completed a cornea/external disease fellowship.
A retrospective review of all patients treated with topical interferon alfa-2b between April 1997 and June 2005 was conducted. A
Results
Twenty-eight eyes of 26 CIN patients were treated with topical interferon alfa-2b drops. Complete clinical resolution of the CIN lesions was achieved in 27 of the 28 eyes treated (96.4%). Figure 1 demonstrates slit-lamp photographs of CIN lesions before treatment with topical interferon alfa-2b and comparisons of the same eye after clinical resolution. One of the 28 eyes treated (3.6%) had only a partial response to treatment and could not be included in the statistical analysis.
The
Discussion
Conjunctival and corneal intraepithelial neoplasia is the most common neoplasm of the ocular surface. The traditional treatment has been wide local surgical excision with adjunctive cryotherapy to the surgical margins in a double freeze/slow thaw technique. Pathologic examination of the excised margins had been important because many lesions were incompletely excised due to diffuse lateral growth. These were associated with a higher incidence of recurrence after surgery.34 Conjunctival and
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Manuscript no. 2007-396.
The authors have no financial interest in any of the products or instruments used in the study.