Elsevier

Ophthalmology

Volume 116, Issue 7, July 2009, Pages 1264-1270.e1
Ophthalmology

Original article
Comparison of Retinal Nerve Fiber Layer Thickness Measured by Cirrus HD and Stratus Optical Coherence Tomography

https://doi.org/10.1016/j.ophtha.2008.12.045Get rights and content

Purpose

To study the relationship between retinal nerve fiber layer (RNFL) thickness measured by time domain (Stratus) and spectral domain (Cirrus HD) optical coherence tomography (OCT).

Design

Cross-sectional study.

Participants

Sixty healthy participants, 48 glaucoma suspects, and 55 subjects with glaucoma.

Methods

Participants were imaged by a single trained operator using the Stratus OCT (fast RNFL scan mode) and Cirrus HD-OCT (optic disc cube mode) at the same visit.

Main Outcome Measures

The RNFL thickness as measured by the Stratus OCT (fast RNFL scan mode) and Cirrus HD-OCT (optic disc cube mode) was compared (paired t test). The relationship between RNFL thickness measurements of the 2 OCTs were evaluated using a Pearson correlation analysis. The presence of abnormal classification, as determined by using an internal normative data base in each machine was compared (chi-square test). The sensitivity and specificity of normative classification of 2 OCT measurements were calculated.

Results

Average RNFL thickness as determined by the 2 OCT machines was correlated (r = 0.94; P<0.001), but was significantly different with the 2 machines (Stratus, 98.0 μm, standard deviation [SD] 18.0; Cirrus, 85.6 μm, SD 14.6; P<0.001). The Cirrus HD-OCT classified a significantly higher percentage of eyes as abnormal (Stratus, 12.9%; Cirrus, 23.3%; P<0.001) in average RNFL thickness. Cirrus OCT demonstrated higher sensitivity and specificity (63.6% and 100%) than Stratus OCT (40.0% and 96.7%) in normative classification of average RNFL thickness.

Conclusions

There were significant differences in RNFL thickness and normative classification as determined by Stratus OCT and Cirrus HD-OCT despite an excellent correlation of RNFL thickness measurement. Overall sensitivity and specificity were higher with Cirrus OCT. These findings are particularly relevant when an individual undergoes longitudinal follow-up with different OCTs.

Financial Disclosure(s)

The authors have no commercial or proprietary interest in any of the materials discussed in this article.

Section snippets

Subjects

All study subjects were recruited prospectively in a consecutive manner from the glaucoma clinic and examined between March 2008 and August 2008 at the Asan Medical Center, Seoul, Korea. At the initial evaluation, all subjects underwent a complete ophthalmologic examination including medical, ocular, and family history; visual acuity testing; Humphrey field analyzer (HFA) Swedish Interactive Threshold Algorithm 24-2 full-threshold test (Car Zeiss Meditec, Inc); multiple intraocular pressure

Results

Among the 163 participants, 75 were women, 88 were men, and all were Asian. Among 163 eyes, 55 eyes had glaucoma, 48 were GS subjects, and 60 were healthy subjects. The mean ± standard deviation age of each group was 53.7±10.9, 53.3±11.3, and 51.3±12.6 years, respectively. The average mean deviation of each group was −5.91±5.68 dB, −0.85±1.48 dB, and −0.67±1.48 dB, respectively. The VF outcomes and OCT measurements of the glaucoma, GS subjects, and healthy groups are summarized in Table 1. Both

Discussion

With the use of both technologies, significant structural differences were observed among healthy eyes, GS eyes, and glaucomatous eye in our series. This finding is consistent with previous studies,3, 18 which reported RNFL thickness measured with scanning laser polarimetry or OCT to be significantly lower in glaucomatous subjects compared with GS subjects. The ability to detect differences between GS eyes and glaucomatous eyes with Cirrus HD-OCT as in our series may reflect its usefulness as a

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  • Cited by (0)

    Manuscript no. 2008-1201.

    Financial Disclosure(s): The authors have no commercial or proprietary interest in any of the materials discussed in this article.

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