RT Journal Article
SR Electronic
T1 Time course of changes in ocular wavefront aberration after instillation of 0.5% timolol gel-forming solution
JF British Journal of Ophthalmology
JO Br J Ophthalmol
FD BMJ Publishing Group Ltd.
SP 433
OP 439
DO 10.1136/bjo.2009.164061
VO 94
IS 4
A1 Takahiro Hiraoka
A1 Masakazu Daito
A1 Fumiki Okamoto
A1 Takahiro Kiuchi
A1 Yoko Hirohara
A1 Toshifumi Mihashi
A1 Tetsuro Oshika
YR 2010
UL http://bjo.bmj.com/content/94/4/433.abstract
AB Aims To investigate the influence of 0.5% timolol gel-forming solution on ocular wavefront aberrations.Methods In 17 normal volunteers, ocular aberration was assessed before and 5 min, 30 min, 1 h, 2 h, 3 h, 6 h and 12 h after instillation of timolol gel-forming solution. Ocular aberration was sequentially measured over a period of 10 s, and the root-mean-square (RMS) of the second-, third-, fourth- and total higher-order aberrations (HOAs) were determined. From the time course of changes in total HOAs in 10 s, the stability index (SI) and fluctuation index (FI) were calculated. The authors also investigated sequential changes in specific Zernike components such as vertical coma, horizontal coma and spherical aberration.Results No significant changes in second-order RMS were observed (p=0.452, repeated-measures ANOVA). Topical instillation significantly increased HOAs such as third-, fourth- and total higher-order RMS (p=0.023, p=0.007 and p=0.003, respectively). Multiple comparison analysis revealed significant increases in HOAs 5 min after instillation (p=0.005 for third-, p=0.001 for fourth- and p<0.001 for total higher-order RMS, Dunnett post hoc test). FI increased significantly 5 min after instillation (p=0.013), but SI did not change significantly. With respect to sequential changes in specific components, significant changes were observed in vertical coma (p=0.004, repeated-measures ANOVA) and horizontal coma (p=0.005), but not in spherical aberration.Conclusion Instillation of timolol gel-forming solution significantly degrades optical quality of the eye for approximately 5 min by increasing HOAs, which may cause blurred vision.