RT Journal Article
SR Electronic
T1 Ocular Manifestations Associated with Murine Typhus
JF British Journal of Ophthalmology
JO Br J Ophthalmol
FD BMJ Publishing Group Ltd.
DO 10.1136/bjo.2008.156059
A1 Moncef Khairallah
A1 Salim Ben Yahia
A1 Adnene Toumi
A1 Bechir Jelliti
A1 Chawki Loussaief
A1 Foued Ben Romdhane
A1 Riadh Messaoud
A1 Mohamed Chakroun
YR 2009
UL http://bjo.bmj.com/content/early/2009/05/03/bjo.2008.156059.abstract
AB Aims: To characterize and analyze ocular manifestations associated with acute murine typhus (MT), an infectious disease caused by Rickettsia typhi. Methods: Nine consecutive patients (18 eyes) with serologically confirmed MT at the acute stage were enrolled in this prospective, noncomparative study. All patients underwent complete ophthalmic examination, including dilated biomicroscopic fundus examination, fundus photography, fluorescein angiography (FA), and indocyanine green (ICG) angiography. Results: Of 9 patients, 8 (88.9%) had bilateral ocular involvement related to MT, with (n=3) or without (n=5) associated ocular symptoms. Findings included mild vitreous inflammation (10 eyes; 55.6%), white retinal lesions (9 eyes; 50%), retinal hemorrhages (4 eyes; 22.2%), retinal vascular leakage (7 eyes; 38.9%), hypofluorescent choroidal dots on FA and/or ICG angiography (11 eyes; 61.1%), optic disc swelling (2 eyes; 11.1%), optic neuritis (1 eye; 5.6%), and optic disc staining (11 eyes; 61.1%). All ocular findings had a self-limited course. Conclusion: Ocular involvement is frequently observed in acute MT. A systematic fundus examination, complemented by angiography in selected cases, may be helpful in establishing an early clinical diagnosis of the disease while serologic testing is pending.