TY - JOUR T1 - Ruthenium-106 brachytherapy for iris and iridociliary melanomas JF - British Journal of Ophthalmology JO - Br J Ophthalmol DO - 10.1136/bjophthalmol-2017-310688 SP - bjophthalmol-2017-310688 AU - Marina Marinkovic AU - Nanda Horeweg AU - Mirjam S Laman AU - Jaco C Bleeker AU - Martijn Ketelaars AU - Femke P Peters AU - Gre P M Luyten AU - Carien L Creutzberg Y1 - 2017/11/09 UR - http://bjo.bmj.com/content/early/2017/11/09/bjophthalmol-2017-310688.abstract N2 - Background and purpose To evaluate ruthenium-106 (Ru106) brachytherapy as eye-conserving treatment of iris melanomas (IMs) and iridociliary melanomas (ICMs).Materials and methods Eighty-eight patients received Ru106 brachytherapy between 2006 and 2016. Primary outcome was local control, and secondary outcomes were metastasis, survival, eye preservation, complications and visual acuity (VA).Results Overall median follow-up was 36 months. Of 88 patients, 58 (65.9%) had IM and 30 (34.1%) had ICM. ICM were on average larger and more advanced than IM. Local failure-free survival at 3 years was 98.9% (SE 1.2%). Metastasis-free survival was 98.2% (SE 1.8%) at 3 years; no deaths due to melanoma occurred during follow-up. Eye preservation rate was 97.7%. Treatment-related toxicities were mostly mild and observed in 80.7% of the patients. Common toxicities were worsening of pre-existing or new cataract (51.1%), dry eyes (29.5%) and glaucoma (20.5%). VA was not affected by Ru106 brachytherapy, with only 2.3% having VA <0.33 (low vision) at follow-up.Conclusions Ru106 for IM and ICM yielded excellent local control (98.9%) and eye preservation (97.7%). Toxicities were common, but mostly mild and transient. Moreover, Ru106 did not affect visual acuity. ER -