S-antigen (S-Ag) and interphotoreceptor retinoid binding protein (IRBP) intranasal tolerance therapy suppresses RE induced EAU to the same extent as RE tolerance therapy
| Tolerising antigen | Incidence (eyes) | Clinical score | Histological score |
| RE | 16/16 | 2 | 2.25 |
| IRBP + S-Ag | 8/8 | 1.75 | 2.13 |
| IRBP | 8/8 | 1.25 | 2.13 |
| PBS | 16/16 | 4 | 3.5 |
All animals were immunised with 250 μg/rat of retinal extract (RE). This table represents a combination of two experiments.
↵20 μg/ml of S-Ag and 50 μg/ml of IRBP were used during tolerising process.
↵Suppression of histological disease day 21 after immunisation, compared with control animals (phosphate buffered saline, PBS) is significant; p<0.02.