Table 1

Two point LOD score values for a number of genetic markers linked to loci of ophthalmic and auditory significance showing exclusion of these loci in family TCD ZMK 92

Marker		Recombination fraction θ		Locus excluded		Disease excluded
Marker		0.00	0.001	Locus excluded		Disease excluded		0.05	0.10	0.15	0.20	0.25	0.30
D1S201	−99.9	−9.19	−2.59	−0.94	−0.17	0.22	0.39	0.44	1p	ad hearing loss
D1S238	−99.9	−9.71	−3.10	−1.45	−0.69	−0.29	−0.1	−0.31	1q	ar RP
D1S213	−99.9	−9.18	−3.48	−1.92	−1.09	−0.58	−0.27	−0.01	1q	ar RP
D1S249	−99.9	−16.71	−5.16	−3.38	−2.39	−1.67	−1.13	−0.72	1q	ar RP, USH1A
D3S196	−99.9	−9.19	−1.67	−0.66	−0.28	−0.14	−0.11	−0.12	3q21-25	USH3
D3S1279	−99.9	−5.10	−1.35	−0.43	−0.02	0.18	0.26	0.27	3q21-25	USH3
D3S47	−99.9	−17.22	−3.92	−1.86	−0.83	−0.24	0.09	0.26	3q, RHO	ad RP
D3S621	−99.9	−10.58	−2.39	−1.20	−0.62	−0.30	0.10	0.02	3q, RHO	ad RP
RDS	−99.9	−17.00	−4.40	−2.37	−1.35	−0.74	−0.37	−0.15	6p, RDS	ad RP
TCTE1	−99.9	−7.67	−2.32	−1.24	−0.68	−0.34	−0.14	−0.03	6p, RDS	ad RP
D4S43	−99.9	−6.90	−2.08	−1.37	−0.96	−0.69	−0.52	−0.41	4p16.3, βPDE	ar RP
D4S412	−99.9	−23.23	−6.51	−3.76	−2.29	−1.37	−0.76	−0.37	4p16.3, βPDE	ar RP
D4S1599	−99.9	−18.91	−5.61	−3.49	−2.36	−1.63	−1.13	−0.76	4p16.3, βPDE	ar RP
D4S231	−99.9	−16.47	−4.73	−2.81	−1.79	−1.14	−0.71	−0.43	4p14–q13, cGMP	ar RP
D4S428	−99.9	−11.22	−2.93	−1.64	−0.97	−0.56	−0.29	−0.12	4p14–q13, cGMP	ar RP
D5S210	−99.9	−5.69	−1.80	0.76	−0.27	−0.07	−0.12	0.15	5q	ad hearing loss
D5S414	−99.9	−12.82	−4.22	−1.98	−0.89	−0.28	0.05	0.20	5q	ad hearing loss
FIB5	−99.9	−12.52	−3.95	−1.75	−0.70	−0.13	0.17	0.28	5q	ad hearing loss
D7S460	−99.9	−14.00	−3.94	−2.21	−1.28	−0.72	−0.37	−0.17	7p	ad RP
D7S493	−99.9	−10.16	−2.02	−0.87	−0.34	−0.76	0.57	0.11	7p	ad cystoid maculopathy
D7S435	−99.9	−17.83	−5.31	−3.03	−1.84	−1.12	−0.64	−0.30	7p	ad RP, ad cystoid maculopathy
D7S486	−99.9	−24.56	−7.74	−5.00	−3.41	−2.40	−1.67	−1.14	7q	ad RP
CFTR	−99.9	−22.62	−6.03	−3.43	−2.10	−1.30	−0.8	−0.49	7q	ad RP
D8S84	−99.9	−6.52	−2.16	−1.35	−0.91	−0.63	−0.43	−0.30	8q12	ad RP
D8S165	−99.9	−2.08	−0.53	−0.37	−0.29	−0.22	−0.16	−0.16	8q12	ad RP
D8S87	−99.9	−6.78	−1.84	−1.08	−0.68	−0.44	−0.28	−0.17	8q12	ad RP
D8S260	−99.9	−31.31	−9.59	−6.05	−4.14	−2.82	−2.018	−1.37	8q12	ad RP
D8S283	−99.9	−22.02	−6.97	−4.47	−3.10	−2.17	−1.50	−1.00	8q12	ad RP
D8S373	−99.9	−27.75	−7.81	−4.63	−2.97	−1.93	−1.23	−0.74	8qter	AMD
D11S527	−99.9	−15.82	−3.79	−1.83	−0.85	−0.28	−0.5	0.23	11q13	VMD2, USH1B
D11S871	−99.9	−14.62	−3.08	−1.35	−0.52	−0.08	0.16	0.24	11q13	VMD2, USH1B
D11S419	−99.9	−7.19	−2.16	−1.32	−0.86	−0.56	−0.36	−0.21	11p	USH1C
INT2	−99.9	−16.2	−4.52	−2.65	−1.65	−1.03	−0.61	−0.33	11q13	USH1B,adFEVR
D11S35	−99.9	−13.31	−1.92	−0.35	0.32	0.61	0.67	0.59	11q13	ad FEVR
D13S158	−99.9	−27.00	−7.17	−4.03	−2.40	−1.41	−0.78	−0.38	13q34	ad Stargardt-like macular degeneration
D13S175	−99.9	−6.78	−2.91	−1.81	−1.21	−0.81	−0.53	−0.33	13cen	ad and ar hearing loss
D17S938	−99.9	−19.2	−4.37	−2.12	−1.03	−0.42	−0.08	0.08	17p	ad RP
D17S796	−99.9	−15.12	−3.59	−1.84	−0.99	−0.51	−0.23	−0.09	17p	ad RP
D17S849	−99.9	−15.59	−3.98	−2.19	−1.29	−0.75	−0.42	−0.22	17p	ad RP
D19S210	−99.9	−14.37	−3.47	−1.80	−0.96	−0.46	−0.15	0.26	19q13.4	ad RP
D22S283	−99.9	−18.9	−5.60	−3.48	−2.36	−1.65	−1.15	−0.78	22q	Sorsby's macular dystrophy

ad = autosomal dominant; ar = autosomal recessive; US = Usher syndrome; AMD = atypical macular dystrophy; VMD = vitelliform macular dystrophy; FEVR = familial exudative vitreoretinopathy.