Responses of ocular arteries to dilator agonists
| Agonist | Artery | Species | Endothelium dependent | Receptor | Mediator |
|---|---|---|---|---|---|
| Acetylcholine | Ophthalmic: | human, porcine | + | NO | |
| canine | − | M/N | PGI2/NO(neurogenic) | ||
| feline | + | ||||
| Ciliary: | human, porcine | + | |||
| Retinal: | bovine | + | M | NO | |
| canine | − | M/N | PGI2/NO(neurogenic) | ||
| Bradykinin | Ophthalmic: | human | + | NO | |
| porcine | + | NO/EDHF? | |||
| Ciliary: | porcine | + | B2 | NO/EDHF? | |
| Histamine | Ophthalmic: | human | + | H1/H2 | NO/? |
| canine | |||||
| external | +/− | H1/H2 | PGI2 | ||
| internal | − | H2 | Not PGI2 | ||
| Retinal: | bovine | + | H1/H2 | NO/PGI2 | |
| Substance P | Ophthalmic: | canine | + | NO/PGI2 | |
| Retinal: | canine | + | NO | ||
| β Antagonists | Ciliary: | porcine | − | Ca2+ antagonism? | |
| Retinal: | bovine | − | Ca2+ antagonism? | ||
| PGI2 | Ophthalmic: | canine | |||
| Retinal: | bovine | ||||
| PGE2 | Ophthalmic: | canine | |||
| SNP | Ophthalmic: | canine | − | ||
| Ciliary: | human, porcine, canine | − | |||
| Retinal: | bovine | − | |||
| SIN-1 | Ophthalmic: | porcine | − | ||
| Ciliary: | porcine | − | |||
| GTN | Retinal: | canine | − | ||
| NO | Ophthalmic: | canine | − |
Muscarinic/nicotinic receptor (M/N), nitric oxide (NO), prostacyclin (PGI2), bradykinin receptor (B2), endothelium derived hyperpolarising factor (EDHF), histamine receptor (H1/H2), prostaglandin E2(PGE2), sodium nitroprusside (SNP), 3-morpholinosydnonimine (SIN-1), glyceryl trinitrate (GTN).