Results of pupillary diameter, fluorescein test, break up time, and IOP after instillation of one drop of carteolol with and without preservative (comparison by analysis of variance (SD))
| Carteolol without benzalkonium | Carteolol with preservative | |
|---|---|---|
| Pupil diameter (mm) | ||
| Baseline | 3.1 (0.8) | 3.3 (0.7) |
| T0 + 30 minutes | 3.1 (0.7) | 3.3 (0.7) |
| T0 + 1 hour | 3.3 (0.8) | 3.1 (0.7) |
| T0 + 3 hours | 3.2 (0.9) | 3.3 (0.7) |
| Fluorescein test (cotation 0–4) | ||
| Baseline | 0 | 0 |
| T0 + 30 minutes | 0.4 (0.8) | 0.2 (0.4) |
| T0 + 1 hour | 0.4 (0.8) | 0.3 (0.5) |
| T0 + 3 hours | 0.4 (0.7) | 0.3 (0.7) |
| Break up time (seconds) | ||
| Baseline | 9.0 (5.1) | 10.4 (5.9) |
| T0 + 30 minutes | 8.1 (5.4) | 7.9 (5.7) |
| T0 + 1 hour | 7.3 (5.9) | 7.4 (6.4) |
| T0 + 3 hours | 7.9 (5.5) | 6.1 (3.9) |
| Intraocular pressure (mm Hg) | ||
| Baseline | 13.8 (1.6) | 13.7 (1.9) |
| T0 + 30 minutes | 10.3 (1.7) | 11.3 (1.6) |
| T0 + 1 hour | 10.5 (1.9) | 10.1 (1.4) |
| T0 + 3 hours | 10.5 (1.9) | 10.8 (1.9) |