Values (mean (SD)) for the mean blood pressure, heart rate, and intraocular pressure (IOP) before and after application of the test drug
| Mean blood pressure (mm Hg) | Heart rate (beats/min) | IOP (mm Hg) | ||||||
|---|---|---|---|---|---|---|---|---|
| Before | After | Before | After | Before | After | |||
| Topical placebo | 93 (10) | 91 (10) | 87 (16) | 77 (17) | 13 (20 | 12 (2) | ||
| Topical metipranolol | 92 (9) | 93 (11) | 83 (16) | 79 (16) | 14 (2) | 11 (3) | ||
| Systemic placebo | 94 (6) | 91 (9) | 82 (16) | 77 (14) | 14 (2) | 13 (2) | ||
| Systemic metipranolol | 93 (8) | 87 (9) | 86 (18) | 62 (11) | 13 (2) | 10 (2) | ||
↵Significant differences between the mean values before and after application of the test drug; p<0.05; Student’st test.