Randomised prospective multicentre study on tPA in cases with fibrin formation after cataract surgery
(A) Incidence of posterior capsule opacification and regenerative secondary cataract | |||||||
---|---|---|---|---|---|---|---|
Days after treatment | tPA (n=44) | Standard therapy (n=41) | Statistical significance | ||||
Posterior capsule opacification | |||||||
1 | 15% | 22.1% | p=0.36 | ||||
2 | 13.6% | 24.6% | p=0.21 | ||||
14 | 34.1% | 51.2% | p=0.06 | ||||
90 | 53.5% | 75.7% | p=0.027 | ||||
Posterior capsule regenerative secondary cataract | |||||||
1 | 4.9% | 2.5% | p=0.57 | ||||
2 | 4.8% | 0% | p=0.17 | ||||
14 | 4.8% | 0% | p=0.17 | ||||
90 | 10% | 20.6% | p=0.2 | ||||
(B) Posterior capsule opacification 1 and 90 days after treatment | |||||||
Days after treatment | tPA | Standard therapy | |||||
1 | 90 | 1 | 90 | ||||
None | 85% | 46.5% | 76.9% | 24.3% | |||
Mild | 10% | 30.2% | 12.8% | 32.4% | |||
Moderate | 2.5% | 20.9% | 10.3% | 40.5% | |||
Severe | 2.5% | 2.3% | 0% | 2.7% |
U test: day 1: p=0.36; day 90: p=0.027; standard treatment group: n=41; tPA group: n=44.