Table 3

Mononuclear cell infiltration and eosinophil granule proteins in the conjunctiva of cicatricial pemphigoid

Antibodies		Epithelium				Subepithelium
Antibodies		Chronic	Subacute			Chronic	Subacute
Mononuclear cell infitrate:
CD45	27.2 (15.8)	39.6 (13.7)		48.3 (15.4)	62.9 (14.3)
CD3	9.7 (6.5)	15.6 (4.5)		20.3 (3.7)	37.2 (5.6)^**
HLA-DR	34.1 (9.3)	42.2 (14.6)		39.3 (6.2)	76.8 (11.9)^**
Human eosinophil granule proteins:
EG1	0.01 (0.01)	1.44 (0.44)^*		0.13 (0.08)	1.75 (0.4)^**
EG2	0.14 (0.06)	0.88 (0.2)^*		0.39 (1.07)	1.5 (0.19)^**
BMK-13	0.08 (0.08)	0.88 (0.38)^*		0.17 (0.1)	2.25 (0.48)^**

↵Cell numbers/high power field (450×); mean (SEM).
↵Cellular and extracellular staining within high power field (× 450): 0 = no staining; 1+ = few foci containing light amounts of staining; 2+ = scattered foci with intense staining or larger area with light staining; 3+ = intensive staining throughout large areas.^*p<0.05/^**p<0.005 by Mann–Whitney U test comparing subacute and chronic disease. EG1=antibody directed against stored and secreted eosinophil cationic protein; EG2=antibody directed against secreted eosinophil cationic protein or eosinophil derived neurotoxin; BMK-13 = antibody directed against major basic protein.