Effects of dexamethasone (DEX) and cyclosporin A (CSA) on orbital fibroblasts (OF) IL-8 and MCP-1 production
| Stimulant | IL-8 (ng/ml) immunosuppressive | MCP-1 (ng/ml) immunosuppressive | |||||
|---|---|---|---|---|---|---|---|
| None | DEX (10-6M) | CSA (30 ng/ml) | None | DEX (10-6 M) | CSA (30 ng/ml) | ||
| None (control) | 13.0 (1.8) | 13.7 (0.6) | 12.6 (0.7) | 8.5 (0.1) | 5.8 (0.4) | 6.3 (0.2) | |
| IL-1 0.2 ng/ml | 23.3 (3.0) | 18.4 (1.0) | 54.0 (7.7) | 12.1 (0.8) | 9.6 (0.8) | 8.2 (0.7) | |
| IL-1 2.0 ng/ml | 61.6 (0.8) | 33.8 (4.0) | 112.3 (1.6) | 13.2 (1.1) | 7.4 (0.8) | 6.3 (0.3) | |
| IL-1 20 ng/ml | 78.4 (3.1) | 38.9 (7.6) | 188.7 (31.5) | 22.6 (0.6) | 13.9 (2.0) | 21.4 (3.4) | |
Numbers represent mean concentration (SEM) (ng/ml).
↵Denotes p<0.05 compared with control (unstimulated) or rIL-1β stimulation.