Characteristics of the IDDM patients grouped by the severity of the diabetic retinopathy
| Normal subjects | IDDM none to minimal non-proliferative retinopathy (RP score 10, 20) | IDDM moderate non-proliferative retinopathy (RP score 30) | IDDM quiescent proliferative retinopathy (RP score 50) | IDDM severe non-proliferative or active proliferative retinopathy (RP score 40, 60) | |
|---|---|---|---|---|---|
| Subjects | 13 | 9 | 13 | 5 | 11 |
| Age (years) | 34 (8) | 29 (6)* | 35 (7) | 36 (7) | 36 (7) |
| Duration of diabetes (years) | — | 18 (6)† | 21 (8) | 25 (5) | 25 (4) |
| Body mass index (kg/m2) | 25.3 (3.2) | 24.5 (1.6) | 24.2 (3.1) | 24.4 (2.5) | 25.5 (2.0) |
| Body fat (%) | 17 (5) | 17 (5) | 19 (6) | 16 (4) | 16 (4) |
| HbA1c (%) | 5.2 (0.5) | 7.8 (0.8)**,† | 8.8 (1.4) | 7.8 (0.8) | 9.2 (1.0) |
| Urinary albumin excretion (μg/min) | 9 (4) | 7 (3) | 10 (9) | 208 (349)†† | 602 (1495)†† |
| Blood pressure, systolic (mmHg) | 126 (18) | 120 (11) | 122 (11) | 128 (7) | 133 (19) |
| Blood pressure, diastolic (mmHg) | 72 (15) | 73 (9) | 74 (4) | 78 (7) | 79 (10) |
| Insulin dose (IU/ffm/d) | — | 0.75 (0.28) | 0.94 (0.27) | 0.80 (0.20) | 0.81 (0.16) |
| Serum total renin (ng/l) | 201 (88)‡‡ ‡,§ | 270 (43) | 337 (106) | 338 (183) | 596 (268)†††,‡‡ |
↵p<0.001 for normal subjects vIDDM patients; **p<0.01 for IDDM patients with RP score 10 or 20v patients with RP score 40 or 60, *p<0.05 for IDDM patients with RP score 10 or 20 vpatients with RP score 40 or 60. †††p<0.001 for IDDM patients with RP score 40 or 60 v patients with RP score 10 or 20 and normal subjects, ††p<0.01 for IDDM patients with RP score 50, 40 or 60 v other IDDM patients,†p<0.05 for IDDM patients with RP score 10 or 20v patients with RP score 50.‡‡‡p<0.001 for normal subjects v IDDM patients with RP core 30, 40, or 60, ‡‡p<0.01 for IDDM patients with RP score 40 or 60 v patients with RP score 30 or 50. ‡p<0.05 for IDDM patients with RP score 10 or 20v patients with RP score 30. §p<0.05 for normal subjects v IDDM patients with RP score 10 or 50. Data are expressed as mean and standard deviation of the mean (SD).