Clinical characteristics of two types of dry eye after allogeneic SCT
| Severe dry eye (n=10) | Mild dry eye (n=12) | Non-dry eye (n=22) | ||
|---|---|---|---|---|
| Mean age (years) (SD) | 31.8 (7.9) | 39.5 (6.4) | 27.7 (10.7) | |
| Sex | ||||
| M | 4 (40.0%) | 9 (75.0%) | 15 (68.2%) | NS |
| F | 6 (60.0%) | 3 (25.0%) | 7 (31.8%) | |
| Median onset (days) | 196 (115) | 149 (63) | NS | |
| Stem cell source | ||||
| related donor | 5 (50%) | 7 (58.3%) | 17 | NS |
| unrelated donor | 5 (50%) | 5 (41.7%) | 5 | |
| Acute GVHD (+) | 8 (80.0%) | 9 (75.0%) | 11 (50%) | NS |
| Acute GVHD (−) | 2 (20.0%) | 3 (25.0%) | 11 (50%) | |
| Chronic GVHD (+) | 10 (100%) | 9 (75.0%) | 8 (36.4%) | p<0.001 |
| Chronic GVHD (−) | 0 (0%) | 3 (25.0%) | 14 (63.6%) | |
| MGD (+) | 10 (100%)* ** | 6 (50.0%)* | 5 (22.7%)** | p<0.05*, p<0.001** |
| MGD (−) | 0 (0%) | 6 (50.0%) | 17 (77.3%) | |
| MGD score | 1.8 (0.4)* ** | 0.7 (0.87)* | 0.4 (0.7)** | p<0.005*, p<0.001** |
GVHD = graft versus host disease in organs other than the eyes; MGD = meibomian gland dysfunction; SCT = stem cell transplantation.