Semiquantitative analysis of TGF-β immunohistochemistry in human optic nerve heads
| TGF-β1 | TGF-β2 | |||||||
|---|---|---|---|---|---|---|---|---|
| Prelamina/lamina | Prelamina | Lamina | ||||||
| Astrocytes | Vessels | Astrocytes | Vessels | Astrocytes | Vessels | |||
| Fetal (n=3) | − | + | ++ | + | ++ | + | ||
| Normal (n=4) | − | +/− | − | − | − | − | ||
| Mild glaucoma (n=4) | − | +/− | ++ | + | ++ | + | ||
| Advanced glaucoma (n=7) | − | + | +++ | + | +++ | + | ||
− = negative staining; +/− = <10% labelled cells; + = 10–25% labelled cells; ++ = 25–50% labelled cells; +++ = >50% labelled cells.