Variable | Patient 1 | Patient 2 | Patient 3 | Patient 4 | Patient 5 | Patient 6 | Patient 7 |
---|---|---|---|---|---|---|---|
Age | 35 | 43 | 43 | 46 | 45 | 58 | 37 |
Sex | M | M | M | M | M | M | M |
Date of diagnosis HIV | Jul 94 | Jan 94 | Feb 96 | Jan 90 | Jun 90 | Jan 96 | Sep 97 |
CMV retinitis: | |||||||
onset | Apr 96 | Feb 96 | Jul 96 | Feb 95 | Jun 95 | Mar 96 | Dec 97 |
laterality | BE | BE | LE | BE | BE | BE | BE |
location (zone) | RE 3, LE 1 and 3 | RE 2 and 3, LE 3 | LE 1, 2, and 3 | RE 1, 2, and 3, LE 2 and 3 | RE 2 and 3, LE 2 and 3 | RE 1, 2, and 3, LE 1, 2, and 3 | RE 1, 2, and 3, LE 1, 2, and 3 |
treatment | IV foscarnet + | IV foscarnet, | IV ganciclovir, | IV then PO ganciclovir, | IV ganciclovir, | IV ganciclovir, | IV + IVit ganciclovir BE, |
IVit ganciclovir LE, | IV cidofovir | PO+ IVit ganciclovir LE | IV+ IVit ganciclovir LE, | PO ganciclovir+ | IV foscarnet, | PO + IVit ganciclovir BE, | |
IV cidofovir, | IVit foscarnet LE, | ganciclovir implant RE | IVit ganciclovir RE, | IVit foscarnet BE, | |||
PO ganciclovir | ganciclovir implant LE | IV cidofovir | IVit ganciclovir LE | ||||
Protease inhibitor | saquinavir, indinavir | indinavir | indinavir | indinavir | indinavir | indinavir | indinavir |
start date | Mar 96 | Oct 96 | Nov 96 | Aug 96 | Apr 96 | Apr 96 | Sep 97 |
CD4 count | |||||||
lowest | 4 | 3 | 13 | 4 | 6 | 10 | 11 |
at onset vitritis | 111 | 97 | 77 | 132 | 126 | 40 | 74 |
rise at onset vitritis | 107 | 94 | 64 | 128 | 120 | 30 | 63 |
IRV | |||||||
anterior chamber | |||||||
cells | BE+ | RE++, LE+ | BE + | RE 0, LE+ | RE+, LE 0 | BE 0 | BE ++ |
KPs | BE | BE | BE | 0 | BE | BE | BE |
vitritis | |||||||
onset | Jun 96 | Mar 97 | Dec 96 | Jan 97 | Jun 96 | Jun 97 | Dec 97 |
interval from starting PI | 3 months | 5 months | 1 month | 5 months | 2 months | 2 months | 3 months |
laterality and severity | BE ++ | BE | LE + | RE silicone oil, LE ++ | RE ++, LE + | BE ++ | BE ++ |
macular changes | BE CMO | RE CMO | nil | nil | nil | nil | LE CMO |
orbital floor steroid injections × number | methylpred ×1 BE triamcinolone ×1 BE | methylpred RE ×3 | methylpred LE ×1 | methylpred LE ×2 | methylpred RE ×2 | methylpred RE ××1 methylpred LE ×3 | triamcinolone LE ×1 |
Snellen acuity | |||||||
before IRV | BE 6/5 | RE 6/6 | LE 6/6 | LE 6/ 5 | BE 6/5 | BE 6/5 | LE 6/18 |
worst during IRV | RE 6/18, LE 6/9 | RE 6/36 | LE 6/9 | LE 6/9 | RE 6/24, L 6/6 | RE 6/18, L6/12 | LE 6/24 |
after treatment for IRV | BE 6/5 | RE 6/18 | LE 6/9 | LE 6/6 | BE 6/6 | BE 6/9 | LE 6/18 |
duration worst acuity | BE 3 wk | 5 wk | indefinite | 2 wk | 6 wk | R 2 mo, L 1 wk | 1 mo |
LE=left eye, RE=right eye, BE=both eyes, IV=intravenous, PO=oral, IVit=intravitreal injection, M=male, mo=month, wk=week, methylpred=methylprednisolone acetate, CMV=cytomegalovirus, IRV=immune recovery vitritis, CMO=cystoid macular oedema, PI=protease inhibitor, CD4 count=CD4 T lymphocyte count (cells/μl).