Growth factor immnuoreactivity in the retinal pigment epithelium following laser photocoagulation
| GFs/GF-R | CTL | Non-lasered regions | Laser treated regions | |||||
|---|---|---|---|---|---|---|---|---|
| 1 Hour –42 days | 1 Hour | 4 Days | 7 Days | 21 Days | 42 Days | |||
| bFGF | ++ | ++ | +/++ | −/+ | +/++ | ++ | ++ | |
| IGF-I | ++ | ++ | ++ | − | − | +/++ | ++ | |
| TGF-β | ++ | ++ | ++/+ ++ | ++ | ++ | ++ | ++ | |
| PDGF-AB | ++ | ++ | ++ | + | + | ++ | ++ | |
| TGF-α | +++ | +++ | − | − | − | +++ | +++ | |
| EGF | +++ | +++ | − | − | +++ | +++ | +++ | |
| EGF-R | ++ | ++ | +/++ | − | + | ++ | ++ | |
GFs=growth factors; GF-R=growth factor receptor; CTL=control (non-lasered retina).
−=negative; +=weak immunoreactivity; ++=moderate immunoreactivity; +++=intense immunoreactivity; /indicates immunoreactivity in different burn areas varied between the limits shown.