Time dependent distribution of phosphorothioate oligodeoxynucleotide (DS 012, 5.0 nmol) in the rat retina following intravitreal injection
| Time (weeks) | Eyes | GCL | INL | ONL | RPE |
|---|---|---|---|---|---|
| 1 | 4 | ++++ | ++++ | +++ | ++++ |
| 2 | 3 | ++++ | ++++ | ++ | ++++ |
| 4 | 3 | ++ | ++ | + | +++ |
| 6 | 3 | ++ | ++ | + | +++ |
| 8 | 3 | + | − | − | ++ |
GCL = ganglion cell layer; INL = inner nuclear layer; ONL = outer nuclear layer; RPE = retinal pigment epithelium. The fluorescent signal was graded by the density and patterns of distribution. − = no signal; + = weak or moderate but scattered; ++ = moderate and evenly distributed; +++ = strong and evenly distributed; ++++ = very strong and evenly distributed.