Some possibilities that may account for the variability of the death rate of ganglion cells in glaucoma
| • Variability of types of ionotropic glutamate receptors associated with ganglion cells |
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| • Variability of numbers of ionotropic glutamate receptors associated with different ganglion cells |
| • Variability of receptor types associated with ganglion cells (for example, nicotinic cholinergic, GABAergic, serotonergic, dopaminergic) |
| • Variability of natural protective mechanisms (for example, calcium binding proteins or chaperones) associated with different ganglion cells |
| • Variability of vascular supply to different ganglion cells |
| • Variability in damage to ganglion cell axons in optic disc area |
| • Susceptibility of ganglion cells associated with size of somata and/or axon diameter |